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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tyrp1isa
iris stromal atrophy
MGI:2178126
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tyrp1isa/Tyrp1isa DBA/2J MGI:2178288
hm2
 		Tyrp1isa/Tyrp1isa involves: C57BL/6J * DBA/2J MGI:2178292
cx3
 		GpnmbR150X/GpnmbR150X
Tyrp1isa/Tyrp1isa 		DBA/2J MGI:2178287
cx4
 		GpnmbR150X/GpnmbR150X
Tyrp1isa/Tyrp1isa 		involves: C57BL/6J * DBA/2J MGI:2178293


Genotype
MGI:2178288
hm1
Allelic
Composition		 Tyrp1isa/Tyrp1isa
Genetic
Background		 DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1isa mutation (3 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye




Genotype
MGI:2178292
hm2
Allelic
Composition		 Tyrp1isa/Tyrp1isa
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1isa mutation (3 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye




Genotype
MGI:2178287
cx3
Allelic
Composition		 GpnmbR150X/GpnmbR150X
Tyrp1isa/Tyrp1isa
Genetic
Background		 DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GpnmbR150X mutation (4 available); any Gpnmb mutation (43 available)
Tyrp1isa mutation (3 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina ganglion cell degeneration ( J:54013 )
• loss of retinal ganglion cells

pigmentation

nervous system
retina ganglion cell degeneration ( J:54013 )
• loss of retinal ganglion cells

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pigment dispersion syndrome DOID:0060680 OMIM:600510
 J:54013




Genotype
MGI:2178293
cx4
Allelic
Composition		 GpnmbR150X/GpnmbR150X
Tyrp1isa/Tyrp1isa
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GpnmbR150X mutation (4 available); any Gpnmb mutation (43 available)
Tyrp1isa mutation (3 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina ganglion cell degeneration ( J:54013 )
• loss of retinal ganglion cells

pigmentation

nervous system
retina ganglion cell degeneration ( J:54013 )
• loss of retinal ganglion cells

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pigment dispersion syndrome DOID:0060680 OMIM:600510
 J:54013




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory