Phenotypes associated with this allele

• Allele Symbol: Serpinc1^tm1Sai
• Allele Name: targeted mutation 1, Hidehiko Saito
• Allele ID: MGI:2178128
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Serpinc1^tm1Sai/Serpinc1^tm1Sai	involves: 129S2/SvPas * C57BL/6J	MGI:2178129
ht2	Serpinc1^tm1Sai/Serpinc1^+	involves: 129S2/SvPas * C57BL/6J	MGI:3037656

Genotype
MGI:2178129

hm1

• Allelic Composition: Serpinc1^tm1Sai/Serpinc1^tm1Sai
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Subcutaneous hemorrhage in Serpinc1^tm1Sai/Serpinc1^tm1Sai mice

muscle

myocardial fiber degeneration ( J:65092 )

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:65092 )

• death occurred between E14.5 and E16.5; no live embryos recovered at E16.5

homeostasis/metabolism

abnormal thrombosis ( J:65092 )

• fibrin deposition found in degenerated myocardium and in the sinusoids of degenerated liver in dead embryos

• although degeneration and hemorrhage was seen in other organs, fibrin deposition was not seen

cardiovascular system

myocardial fiber degeneration ( J:65092 )

hemorrhage ( J:65092 )

• extensive subcutaneous hemorrhage seen in dead embryos

intracranial hemorrhage ( J:65092 )

liver/biliary system

liver degeneration ( J:65092 )

nervous system

intracranial hemorrhage ( J:65092 )

Genotype
MGI:3037656

ht2

• Allelic Composition: Serpinc1^tm1Sai/Serpinc1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

homeostasis/metabolism

increased susceptibility to induced thrombosis ( J:75955 )

• percentage of glomeruli with fibrin deposition increased by lipopolysaccharide challenge and by restraint induced stress

• increased levels of fibrin deposition found in the glomeruli of kidneys as well as myocardium and in the sinusoids of the liver after lipopolysaccharide challenge