About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Map3k3tm1Bisu
targeted mutation 1, Bing Su
MGI:2178133
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Map3k3tm1Bisu/Map3k3tm1Bisu Not Specified MGI:3580326
cn2
Map3k3tm1Bisu/Map3k3tm2Bisu
Tg(Lck-cre)548Jxm/0
involves: C57BL/6 * CBA MGI:3836810


Genotype
MGI:3580326
hm1
Allelic
Composition
Map3k3tm1Bisu/Map3k3tm1Bisu
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k3tm1Bisu mutation (0 available); any Map3k3 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by E11.5, all homozygotes were dead
• normal ratios of homozygotes found until E10

embryo
• reduced number of embryonic blood vessels in the labyrinth layer of the placenta at E9.5
• yolk sac blood vessels lacking by E8 (15-20 somite stage)
• primordial blood plexus was present through E9.5 but dilated and with few red blood vessels

cardiovascular system
• reduced number of embryonic blood vessels in the labyrinth layer of the placenta at E9.5
• less development of blood vessels in the brain
• fewer and less complex intersomic blood vessel
• vasculogenesis was normal but subsequent remodeling failed
• myocardium development severely retarded
• decreased trabeculation
• less complex endocardium around trabeculations
• heart less developed
• little atrial endocardium

muscle
• myocardium development severely retarded
• decreased trabeculation
• less complex endocardium around trabeculations

growth/size/body
• smaller head at E9.5




Genotype
MGI:3836810
cn2
Allelic
Composition
Map3k3tm1Bisu/Map3k3tm2Bisu
Tg(Lck-cre)548Jxm/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k3tm1Bisu mutation (0 available); any Map3k3 mutation (27 available)
Map3k3tm2Bisu mutation (0 available); any Map3k3 mutation (27 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD4+ T cell numbers are reduced by about half in the spleen and lymph nodes
• CD8+ T cell numbers in the spleen and lymph node are only 66% of that found in wild-type
• spleen size is significantly reduced mostly due to a reduction in the number of T cells
• when transferred into a immunocompetent syngeneic host, mutant T cells fail to survive where as wild-type T cells do
• homeostatic proliferation of T cells is defective as determined by competitive reconstitution assays with wild-type lymph node cells in sublethally irradiated hosts
• homeostatic proliferation is also defective in culture when mutant T cell proliferation is driven by the presence of syngeneic dendritc cells
• antigen driven proliferation is normal in these mice

hematopoietic system
• CD4+ T cell numbers are reduced by about half in the spleen and lymph nodes
• CD8+ T cell numbers in the spleen and lymph node are only 66% of that found in wild-type
• spleen size is significantly reduced mostly due to a reduction in the number of T cells
• when transferred into a immunocompetent syngeneic host, mutant T cells fail to survive where as wild-type T cells do
• homeostatic proliferation of T cells is defective as determined by competitive reconstitution assays with wild-type lymph node cells in sublethally irradiated hosts
• homeostatic proliferation is also defective in culture when mutant T cell proliferation is driven by the presence of syngeneic dendritc cells
• antigen driven proliferation is normal in these mice

cellular
• homeostatic proliferation of T cells is defective as determined by competitive reconstitution assays with wild-type lymph node cells in sublethally irradiated hosts
• homeostatic proliferation is also defective in culture when mutant T cell proliferation is driven by the presence of syngeneic dendritc cells
• antigen driven proliferation is normal in these mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory