Phenotypes associated with this allele

• Allele Symbol: Minute
• Allele Name: minute imprinted gene in the Igf2 region
• Allele ID: MGI:2178160
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Minute/Minute	involves: 101/H * C3H/HeH	MGI:3810377
hm2	Minute/Minute	involves: 101/H * C3H/HeH * C57BL/6J * CBA/Ca * M. spretus	MGI:3810376
ht3	Minute/Minute^+	involves: 101/H * C3H/HeH	MGI:3576651
ht4	Minute/Minute^+	involves: 101/H * C3H/HeH * C57BL/6J * CBA/Ca * M. spretus	MGI:2178224
ht5	Minute/Minute^+	involves: 101/H * C3H/HeH * M. m. castaneus	MGI:3576652

Genotype
MGI:3810377

hm1

• Allelic Composition: Minute/Minute
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:65007 )

• mice receiving a mutant allele from both the mother and father die late in development

Genotype
MGI:3810376

hm2

• Allelic Composition: Minute/Minute
• Genetic Background: involves: 101/H * C3H/HeH * C57BL/6J * CBA/Ca * M. spretus

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:75952 )

• die between E15 and E17

Genotype
MGI:3576651

ht3

• Allelic Composition: Minute/Minute⁺
• Genetic Background: involves: 101/H * C3H/HeH

mortality/aging

postnatal lethality, incomplete penetrance ( J:65007 )

• most postnatal lethality of mice with a paternal allele occurres around P4

• Background Sensitivity: survival is enhanced in M. m. castaneus cross

cellular

abnormal imprinting ( J:65007 )

• abnormal imprinting of Igf2 occurs with mice receiving the maternal allele having increased growth rates in utero while mice receiving the paternal allele having decreased in utero growth rates

embryo

embryonic growth retardation ( J:65007 )

• severe growth retardation is seen at E13 through birth in mice inheriting a paternal allele

abnormal placenta weight ( J:65007 )

• placental weight ratios are more severely reduced than fetal weight ratios with mice inheriting a paternal allele

craniofacial

abnormal head shape ( J:65007 )

• mice inheriting a paternal allele exhibit a domed head phenotype

growth/size/body

abnormal head shape ( J:65007 )

• mice inheriting a paternal allele exhibit a domed head phenotype

embryonic growth retardation ( J:65007 )

• severe growth retardation is seen at E13 through birth in mice inheriting a paternal allele

decreased birth body size ( J:65007 )

• at birth, size of mice inheriting a paternal allele is less than 50% of normal

decreased body weight ( J:65007 )

• adults with a paternal allele are only about 60% of the weight of wild-type littermates

postnatal growth retardation ( J:65007 )

• postnatal growth is also reduced in mice inheriting a paternal allele, with weight reaching a minimum at about 4 days of age

• adults with a paternal allele are only about 60% of the weight of wild-type littermates

fetal growth retardation ( J:65007 )

• severe growth retardation is seen at E13 through birth in mice inheriting a paternal allele

Genotype
MGI:2178224

ht4

• Allelic Composition: Minute/Minute⁺
• Genetic Background: involves: 101/H * C3H/HeH * C57BL/6J * CBA/Ca * M. spretus

mortality/aging

neonatal lethality, incomplete penetrance ( J:75952 )

• while the expected number of mice inheriting the paternal allele are present at E18, by P1 only one third of expected mice are present

cellular

abnormal imprinting ( J:75952 )

• abnormal imprinting of Igf2 occurs with mice receiving the maternal allele having increased growth rates in utero while mice receiving the paternal allele having decreased in utero growth rates

embryo

decreased embryo weight ( J:75952 )

• at E13 mice carrying a paternally inherited allele are 83% of wild-type in weight

decreased placenta weight ( J:75952 )

• at E13 placental weight is 78% of wild-type and reaches 56% of wild-type at E18 in mice carrying a paternally inherited mutant allele

increased placenta weight ( J:75952 )

• with embryos inheriting a maternal allele

growth/size/body

decreased birth body size ( J:75952 )

• at birth mice carrying a paternally inherited allele are 55% of wild-type in size

decreased birth weight ( J:75952 )

• at birth, mice carrying a paternally inherited allele are 53% of wild-type weight

decreased body size ( J:75952 )

• in mice carrying a paternally inherited allele the size reduction observed at birth is maintained into adulthood

abnormal embryonic growth/weight/body size ( J:75952 )

• mice inheriting maternal allele measure 113% of wild-type and overgrowth reaches 108% of wild-type by P0

• mice inherting maternal allele have increased prenatal growth rates

decreased embryo weight ( J:75952 )

• at E13 mice carrying a paternally inherited allele are 83% of wild-type in weight

Genotype
MGI:3576652

ht5

• Allelic Composition: Minute/Minute⁺
• Genetic Background: involves: 101/H * C3H/HeH * M. m. castaneus

mortality/aging

postnatal lethality, complete penetrance ( J:65007 )

• Background Sensitivity: survival is enhanced in M. m. castaneus cross