Phenotypes associated with this allele

• Allele Symbol: Foxa3^tm1Khk
• Allele Name: targeted mutation 1, Klaus H Kaestner
• Allele ID: MGI:2178218
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxa3^tm1Khk/Foxa3^tm1Khk	B6.129P2-Foxa3^tm1Khk	MGI:6209480
hm2	Foxa3^tm1Khk/Foxa3^tm1Khk	involves: 129P2/OlaHsd * C57BL/6	MGI:3612881

Genotype
MGI:6209480

hm1

• Allelic Composition: Foxa3^tm1Khk/Foxa3^tm1Khk
• Genetic Background: B6.129P2-Foxa3^tm1Khk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased body fat mass ( J:216477 )

• decreased fat compared to controls when fed a high fat diet

decreased brown fat cell size ( J:216477 )

abnormal beige fat cell morphology ( J:216477 )

• increased beige cell numbers in white adipose tissue

decreased white fat cell size ( J:216477 )

increased adipocyte glucose uptake ( J:216477 )

mortality/aging

extended life span ( J:216477 )

cellular

increased adipocyte glucose uptake ( J:216477 )

increased male germ cell apoptosis ( J:134427 )

• increased apoptosis in the germinal epithelium

abnormal primordial germ cell proliferation ( J:134427 )

• impairment of early germ cell proliferation or survival

growth/size/body

decreased body fat mass ( J:216477 )

• decreased fat compared to controls when fed a high fat diet

decreased susceptibility to weight gain ( J:216477 )

• mice gain less weight on a high fat diet when compared to controls

homeostasis/metabolism

decreased fasting circulating glucose level ( J:72595 )

• after fasting for 24-72 hours, mutant mice had significantly lower blood glucose levels when compared with the control groups

decreased circulating leptin level ( J:216477 )

• in 14 month old mice but not 2 month old mice

increased oxygen consumption ( J:216477 )

decreased hepatic glucose production ( J:72595 )

• a reduction in Glut2 transcripts presumably reduces glucose trasnport from the sites of gluconeogenesis in the liver

increased insulin sensitivity ( J:216477 )

abnormal lipid homeostasis ( J:216477 )

• decreased intrahepatic lipid deposition

decreased circulating cholesterol level ( J:216477 )

• in 14 month old mice but not 2 month old mice

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:134427 )

• testes could not support spermatogenesis throughout the entire germinal epithelium

abnormal Sertoli cell morphology ( J:134427 )

• some of the Sertoli cell nuclei have lost the pyramidal shape normally found

seminiferous tubule degeneration ( J:134427 )

• progressive with age

decreased testis weight ( J:134427 )

reproductive system

increased male germ cell apoptosis ( J:134427 )

• increased apoptosis in the germinal epithelium

abnormal primordial germ cell proliferation ( J:134427 )

• impairment of early germ cell proliferation or survival

abnormal seminiferous tubule epithelium morphology ( J:134427 )

• testes could not support spermatogenesis throughout the entire germinal epithelium

abnormal Sertoli cell morphology ( J:134427 )

• some of the Sertoli cell nuclei have lost the pyramidal shape normally found

seminiferous tubule degeneration ( J:134427 )

• progressive with age

decreased testis weight ( J:134427 )

abnormal spermatogenesis ( J:134427 )

• testes could not support spermatogenesis throughout the entire germinal epithelium

reduced male fertility ( J:134427 )

Genotype
MGI:3612881

hm2

• Allelic Composition: Foxa3^tm1Khk/Foxa3^tm1Khk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:48310 )

• homozygotes are viable, fertile and exhibit no morphologic abnormalities in the stomach, and intestine or liver, despite a 50%-70% reduction in the expression levels of several liver-specific and liver-enriched genes (including phosphoenolpyruvate carboxykinase, transferrin, and tyrosine aminotransferase)