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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mycntm1Jrt
targeted mutation 1, Janet Rossant
MGI:2178220
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mycntm1Jrt/Mycntm1Jrt involves: 129S2/SvPas * C57BL/6J MGI:2180007
ht2
Mycntm1Jrt/Mycntm1Par involves: 129S2/SvPas * C57BL/6J MGI:3620016


Genotype
MGI:2180007
hm1
Allelic
Composition
Mycntm1Jrt/Mycntm1Jrt
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mycntm1Jrt mutation (0 available); any Mycn mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals die shortly after birth

behavior/neurological
• animals do not move after birth

respiratory system
• thin septa, thin and fragile outer surface
• animals gasp for breath after birth




Genotype
MGI:3620016
ht2
Allelic
Composition
Mycntm1Jrt/Mycntm1Par
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mycntm1Jrt mutation (0 available); any Mycn mutation (25 available)
Mycntm1Par mutation (1 available); any Mycn mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• compound heterozygotes start dying at ~E12.5, when 12 out of 42 mutants are found to be dead and necrotic
• no live compound heterozygotes are obtained after E14.5

cardiovascular system
• at E12.5, compound heterozygotes with an edematous neck area exhibit massively dilated jugular veins, indicating cardiac dysfunction
• however, no other major veins are shown to exhibit significant dilation
• at E12.5, compound heterozygotes show a thin subepicardial layer in the ventricular myocardium; the atrial myocardium and inner trabecular layer of ventricles are less severly affected
• at E12.5, the mutant subepicardial ("compact") layer has failed to grow and is as thick as at E10.5
• at E12.5, compound heterozygotes display a thinned myocardium relative to wild-type mice
• at E12.5 and E14.5, compound heterozygotes fail to exhibit proliferation in the subepicardial ("compact") layer of the ventricular myocardium

respiratory system
• at E12.5, compound heterozygotes display an exacerbated branching defect in the lung epithelium relative to Mycntm1Jrt homozygotes, as shown by absence of tertiary branching

homeostasis/metabolism
• at E12.5, 23 out of 42 compound heterozygotes display a large edema in the neck area
• all compound heterozygotes surviving to E14.5 show an edematous neck area

embryo
• at E12.5, 2 out of 42 compound heterozygotes are slightly smaller than wild-type embryos

renal/urinary system
• compound heterozygotes that survive to E14.5 exhibit small but structurally normal kidneys relative to wild-type mice

growth/size/body
• at E12.5, 2 out of 42 compound heterozygotes are slightly smaller than wild-type embryos
• all compound heterozygotes surviving to E14.5 are smaller than wild-type embryos

muscle
• at E12.5, compound heterozygotes show a thin subepicardial layer in the ventricular myocardium; the atrial myocardium and inner trabecular layer of ventricles are less severly affected
• at E12.5, the mutant subepicardial ("compact") layer has failed to grow and is as thick as at E10.5
• at E12.5, compound heterozygotes display a thinned myocardium relative to wild-type mice
• at E12.5 and E14.5, compound heterozygotes fail to exhibit proliferation in the subepicardial ("compact") layer of the ventricular myocardium

nervous system
N
• unlike Mycntm1Par homozygotes, compound heterozygotes do NOT exhibit reduced cranial or spinal ganglia

reproductive system
N
• unlike Mycntm1Par homozygotes, compound heterozygotes do NOT exhibit reduced genital ridges

cellular
• at E12.5 and E14.5, compound heterozygotes fail to exhibit proliferation in the subepicardial ("compact") layer of the ventricular myocardium





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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory