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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myctm2Fwa
targeted mutation 2, Frederick W Alt
MGI:2178233
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myctm2Fwa/Myctm2Fwa involves: 129S6/SvEvTac MGI:2385668
cn2
 		Myctm2Fwa/Myctm2Fwa
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:2385667
cn3
 		Gt(ROSA)26Sortm12(CD2*)Rsky/Gt(ROSA)26Sor+
Myctm2Fwa/Myctm2Fwa
Ighg1tm1(cre)Cgn/Ighg1+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:5444672
cn4
 		Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky/Gt(ROSA)26Sor+
Myctm2Fwa/Myctm2Fwa
Ighg1tm1(cre)Cgn/Ighg1+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:5444673
cn5
 		Myctm2Fwa/Myctm2Fwa
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CD-1 MGI:7485843
cn6
 		Myctm2Fwa/Myc+
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CD-1 MGI:7485842
cn7
 		Fbxw7tm1Kei/Fbxw7tm1Kei
Myctm2Fwa/Myctm2Fwa
Tg(Cd4-cre)1Cwi/? 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3767599
cn8
 		Myctm2Fwa/Myctm2Fwa
Gt(ROSA)26Sortm1Sor/?
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA MGI:3720325
cn9
 		Myctm2Fwa/Myc+
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3720194
cn10
 		Myctm2Fwa/Myctm2Fwa
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3720189


Genotype
MGI:2385668
hm1
Allelic
Composition		 Myctm2Fwa/Myctm2Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:67222 )
• homozygotes are fertile and show no obvious abnormalities




Genotype
MGI:2385667
cn2
Allelic
Composition		 Myctm2Fwa/Myctm2Fwa
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:67222 )
• impaired proliferation response to stimulation; cells do not undergo activation

hematopoietic system
decreased B cell proliferation ( J:67222 )
• impaired proliferation response to stimulation; cells do not undergo activation

cellular
decreased B cell proliferation ( J:67222 )
• impaired proliferation response to stimulation; cells do not undergo activation




Genotype
MGI:5444672
cn3
Allelic
Composition		 Gt(ROSA)26Sortm12(CD2*)Rsky/Gt(ROSA)26Sor+
Myctm2Fwa/Myctm2Fwa
Ighg1tm1(cre)Cgn/Ighg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm12(CD2*)Rsky mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased spleen germinal center size ( J:188564 )
• almost complete ablation of germinal centers in response to T cell dependent immunization
• the few remaining germinal center B cells have escaped cre mediated recombination

hematopoietic system
decreased spleen germinal center size ( J:188564 )
• almost complete ablation of germinal centers in response to T cell dependent immunization
• the few remaining germinal center B cells have escaped cre mediated recombination




Genotype
MGI:5444673
cn4
Allelic
Composition		 Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky/Gt(ROSA)26Sor+
Myctm2Fwa/Myctm2Fwa
Ighg1tm1(cre)Cgn/Ighg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:188564 )
N
• enforced expression of human MYC rescues germinal center formation




Genotype
MGI:7485843
cn5
Allelic
Composition		 Myctm2Fwa/Myctm2Fwa
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:319454 )
• fie before onset of osteosarcoma




Genotype
MGI:7485842
cn6
Allelic
Composition		 Myctm2Fwa/Myc+
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased osteosarcoma incidence ( J:319454 )
• decreased incidence compared to mutant mice wild-type for Myc

mortality/aging
increased tumor-free survival time ( J:319454 )
• survival time is increased compared to mutant mice wild-type for Myc

skeleton
decreased osteosarcoma incidence ( J:319454 )
• decreased incidence compared to mutant mice wild-type for Myc




Genotype
MGI:3767599
cn7
Allelic
Composition		 Fbxw7tm1Kei/Fbxw7tm1Kei
Myctm2Fwa/Myctm2Fwa
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Kei mutation (1 available); any Fbxw7 mutation (84 available)
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:128523 )
N
• unlike in Fbxw7tm1Kei/Fbxw7tm1Kei Tg(CD4-cre)1Cwi mice, the number of double positive thymocytes is normal




Genotype
MGI:3720325
cn8
Allelic
Composition		 Myctm2Fwa/Myctm2Fwa
Gt(ROSA)26Sortm1Sor/?
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal coronal suture morphology ( J:121871 )
• the coronal suture adjacent to the frontal bone has a curvilinear appearance and fails to fuse at the midline
abnormal frontal bone morphology ( J:121871 )
• at 6 weeks, the frontal bone is defective and mostly composed of a cartilaginous membrane
abnormal malleus morphology ( J:121871 )
• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
small malleus manubrium ( J:121871 )
• at 6 weeks, the manubrium is smaller than normal
small malleus ( J:121871 )
• at 6 weeks, the body of the malleus is smaller than normal

hearing/vestibular/ear
abnormal malleus morphology ( J:121871 )
• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
small malleus manubrium ( J:121871 )
• at 6 weeks, the manubrium is smaller than normal
small malleus ( J:121871 )
• at 6 weeks, the body of the malleus is smaller than normal

skeleton
abnormal coronal suture morphology ( J:121871 )
• the coronal suture adjacent to the frontal bone has a curvilinear appearance and fails to fuse at the midline
abnormal frontal bone morphology ( J:121871 )
• at 6 weeks, the frontal bone is defective and mostly composed of a cartilaginous membrane
abnormal malleus morphology ( J:121871 )
• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
small malleus manubrium ( J:121871 )
• at 6 weeks, the manubrium is smaller than normal
small malleus ( J:121871 )
• at 6 weeks, the body of the malleus is smaller than normal

growth/size/body
short nasal bone ( J:121871 )

respiratory system




Genotype
MGI:3720194
cn9
Allelic
Composition		 Myctm2Fwa/Myc+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belly spot ( J:121871 )
• mutant mice display a clearly demarcated white belly spot

integument
belly spot ( J:121871 )
• mutant mice display a clearly demarcated white belly spot




Genotype
MGI:3720189
cn10
Allelic
Composition		 Myctm2Fwa/Myctm2Fwa
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
small nasal bone ( J:121871 )
short nasal bone ( J:121871 )
short snout ( J:121871 )
• mutant mice exhibit a persistently shorter snout
decreased body size ( J:121871 )
• mutant mice are viable but show a ~25% reduction in overall size relative to control littermates
decreased body weight ( J:121871 )
• mutant mice show a ~25% reduction in weight relative to control littermates

pigmentation
variable body spotting ( J:121871 )
• all mutants show coat pigmentation defects involving multiple white patches of various sizes that spare the head
• however, no other neural crest-related defects such as cleft palate, spina bifida or exencephaly are observed

craniofacial
small cranium ( J:121871 )
• mutant mice exhibit a noticeably smaller skull
abnormal frontal bone morphology ( J:121871 )
• frontal bones are defective, with absence of ossification near the metopic region
abnormal parietal bone morphology ( J:121871 )
• the relative size and position of parietal bones is abnormal
abnormal middle ear ossicle morphology ( J:121871 )
• mutant mice display predominantly malleal defects
• in contrast, the structure and size of incus and stapes appears normal
• in addition, normal hair cells are seen in the organ of Corti, utricle, and crista, and no absence of inner or outer hair cell stereocilia is observed
abnormal malleus morphology ( J:121871 )
• the body of malleus is abnormally shaped
• the angle between the manubrium and the body of the malleus is increased
short malleus manubrium ( J:121871 )
• the manubrium is shorter than normal
small malleus ( J:121871 )
• the body of malleus is smaller than normal
short snout ( J:121871 )
• mutant mice exhibit a persistently shorter snout

skeleton
small cranium ( J:121871 )
• mutant mice exhibit a noticeably smaller skull
abnormal frontal bone morphology ( J:121871 )
• frontal bones are defective, with absence of ossification near the metopic region
abnormal parietal bone morphology ( J:121871 )
• the relative size and position of parietal bones is abnormal
abnormal middle ear ossicle morphology ( J:121871 )
• mutant mice display predominantly malleal defects
• in contrast, the structure and size of incus and stapes appears normal
• in addition, normal hair cells are seen in the organ of Corti, utricle, and crista, and no absence of inner or outer hair cell stereocilia is observed
abnormal malleus morphology ( J:121871 )
• the body of malleus is abnormally shaped
• the angle between the manubrium and the body of the malleus is increased
short malleus manubrium ( J:121871 )
• the manubrium is shorter than normal
small malleus ( J:121871 )
• the body of malleus is smaller than normal

hearing/vestibular/ear
abnormal middle ear ossicle morphology ( J:121871 )
• mutant mice display predominantly malleal defects
• in contrast, the structure and size of incus and stapes appears normal
• in addition, normal hair cells are seen in the organ of Corti, utricle, and crista, and no absence of inner or outer hair cell stereocilia is observed
abnormal malleus morphology ( J:121871 )
• the body of malleus is abnormally shaped
• the angle between the manubrium and the body of the malleus is increased
short malleus manubrium ( J:121871 )
• the manubrium is shorter than normal
small malleus ( J:121871 )
• the body of malleus is smaller than normal
abnormal auditory brainstem response ( J:121871 )
• mutant mice display delayed evoked response latencies
conductive hearing impairment ( J:121871 )
• mutant mice show a significant hearing deficit attributed to malleal defects

behavior/neurological
absent pinna reflex ( J:121871 )
• mutant mice do not appear startled in response to a loud noise e.g. clapping of hands

integument
variable body spotting ( J:121871 )
• all mutants show coat pigmentation defects involving multiple white patches of various sizes that spare the head
• however, no other neural crest-related defects such as cleft palate, spina bifida or exencephaly are observed

respiratory system




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Send questions and comments to User Support. 		last database update
11/12/2024
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