mortality/aging
• in intercross litters of heterozygous mice, no homozygous mice are found
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Allele Symbol Allele Name Allele ID |
EgfrWa5 waved 5 MGI:2178387 |
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Summary |
7 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• in intercross litters of heterozygous mice, no homozygous mice are found
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• embryos surviving past E12.5 die by birth or very shortly after
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• morphologically normal at E10.5
• 71% lethality between E10.5 and E12.5
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• defective placentas with phenotypes ranging from mild defects to severely affected
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• reduced spongiotrophoblast at E12.5
• spongiotrophoblast reduction very significant in runted embryos
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• variably compromised labyrinthine layer
• multinucleated labyrinthine trophoblasts
• reduced thickness
• multiple blood pockets found in runted embryos
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• damage from the open eyelids in the form of corneal scarring is dependent on environment, where mice raised in a pathogen free environment have no apparent defects in eye development
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• apart from the open eyelids, the eyes of neonates appear normal
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• the first coat is described as wavy and subsequent coats are scruffy in appearance
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mildly abnormal placentas
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• reduced spongiotrophoblast at E12.5
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• variably compromised labyrinthine layer
• multinucleated labyrinthine trophoblasts
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• born at about half the expected rate
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• heavy death rate over the first 3 weeks of life
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• narrow, asymmetric snout
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• elongated snout
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• narrow, asymmetric snout
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• body weight ranges from 30-50% of controls in mutants that survive for 3 months after birth
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• 25% reduction in body size in mice surviving to 6 weeks of age
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• underdeveloped lower jaw
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• narrow, asymmetric snout
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• elongated snout
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• narrow, asymmetric snout
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• vaginal opening delayed until around 11 months of age
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• no offspring produced by either gender by 3 months of age
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• underdeveloped lower jaw
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• eye defects
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• complete hair loss occurs around 8 weeks of age with resumption of hair growth sometime thereafter
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• reduced postnatal growth although size at birth is normal
• noticeably reduced in size by 1 week of age
• 25% reduction in body size in mice surviving to 6 weeks of age
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• smaller lower jaw
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• smaller lower jaw
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 46% reduction in the number of macroscopic intestinal polyps in comparison to mice heterozygous only for ApcMin at 3 months of age
• no reduction in tumor size
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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