mortality/aging
• animals die at birth or by weaning
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• animals die at birth or by weaning
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Allele Symbol Allele Name Allele ID |
Otx2tm4Sia targeted mutation 4, Shinichi Aizawa MGI:2178747 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• animals die at birth or by weaning
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• animals die at birth or by weaning
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• anterior visceral endoderm (AVE) and anterior definitive endoderm (ADE) form normally in mutants
• anterior axial mesendoderm functions normally in mutants
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• at 10.5 dpc, neural tube has failed to close
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• most skull elements in premandibular and distal components of mandibular regions develop although morphology is distorted
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• most skull elements in premandibular and distal components of mandibular regions develop although morphology is distorted
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• the mesencephalon is malformed
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• at 10.5 dpc, absence of diencephalon is noted
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• the rostral portion of metencephalic regions, including the isthmus, appears to be malformed
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• neural plate loses competence to inductive signals from anterior neural ridge
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• at 10.5 dpc, neural tube has failed to close
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• at 10.5 dpc, rostral aspect of brain appears truncated
• majority of rostral brain fails to develop normally at 10.5 days post-coitum (dpc)
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• at 10.5 dpc, absence of telencephalic vesicles is noted
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• the isthmus appears to be malformed
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• at E18.5 all embryos exhibit exencephaly or anencephaly
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• at E18.5 all embryos exhibit exencephaly or anencephaly
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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