Phenotypes associated with this allele

• Allele Symbol: Sox18^tm1Koop
• Allele Name: targeted mutation 1, Peter Koopman
• Allele ID: MGI:2178809
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox18^tm1Koop/Sox18^tm1Koop	B6.129-Sox18^tm1Koop	MGI:3850352
hm2	Sox18^tm1Koop/Sox18^tm1Koop	involves: 129/Sv * CD-1	MGI:3046058
ht3	Sox18^tm1Koop/Sox18^+	B6.129-Sox18^tm1Koop	MGI:3850353

Genotype
MGI:3850352

hm1

• Allelic Composition: Sox18^tm1Koop/Sox18^tm1Koop
• Genetic Background: B6.129-Sox18^tm1Koop

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:143564 )

• mice die before E14.5

homeostasis/metabolism

skin edema ( J:143564 )

immune system

abnormal lymphatic vessel morphology ( J:143564 )

• lymphatic vessels are finer, denser, and more branched with more loops and fewer blind-ended sacs compared to in wild-type mice

integument

skin edema ( J:143564 )

Genotype
MGI:3046058

hm2

• Allelic Composition: Sox18^tm1Koop/Sox18^tm1Koop
• Genetic Background: involves: 129/Sv * CD-1

pigmentation

darkened coat color ( J:66010 )

• a significant proportion of auchene and zigzag hair types have reduced or no phaeomelanin (yellow) banding which effectively darkens the coat

integument

darkened coat color ( J:66010 )

• a significant proportion of auchene and zigzag hair types have reduced or no phaeomelanin (yellow) banding which effectively darkens the coat

abnormal hair growth ( J:66010 )

• reduction found in proportion of the zigzag hair type (36%) compared to normal (56%)

Genotype
MGI:3850353

ht3

• Allelic Composition: Sox18^tm1Koop/Sox18⁺
• Genetic Background: B6.129-Sox18^tm1Koop

homeostasis/metabolism

skin edema ( J:143564 )

• 2 of 4 mice exhibit mild subcutaneous edema around the head

integument

skin edema ( J:143564 )

• 2 of 4 mice exhibit mild subcutaneous edema around the head