Analysis Tools
cardiovascular system
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• in response to chronic hypoxia (10% O2 for 4 wks) homozygotes fail to exhibit any increase in intralobar pulmonary arterial medial wall thickness, unlike hypoxic wild-type mice where medial wall thickness (% of vessel diameter) is increased by 27-36%
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• in response to chronic hypoxia (10% O2 for 4 wks) homozygotes display a less pronounced RV hypertrophy than hypoxic wild-type mice (41% versus 66% increase in RV/[LV+septum], respectively)
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small heart
(
J:60503
)
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• heart weight is reduced in juveniles but not in early postnatal mice, indicating impaired growth of hearts in the first few weeks after birth
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• in response to chronic hypoxia (10% O2 for 4 wks) homozygotes show a significantly lower increase in RV/body weight than hypoxic wild-type mice
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• abnormal reactive hyperemic response to coronary occlusion, with a lower overall flow-debt repayment during the initial 60 sec of reperfusion, although peak hyperemic flow was normal
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• in response to chronic hypoxia (10% O2 for 4 wks) homozygotes fail to display any increase in right ventricular systolic pressure (RVSP), unlike hypoxic wild-type mice where RVSP is increased by 70% relative to normoxic controls
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• unlike wild-type controls, homozygotes fail to develop pulmonary hypertension in response to chronic hypoxia due to absence of pulmonary vascular remodeling
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• peak contracture during ischemia is greater, diastolic pressure is elevated during reperfusion and recovered only minimally, and the recovery of contractile function is slightly depressed throughout reperfusion, with the rate-pressure product lower at 30 min compared with controls
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• corneal injection of a plasmid encoding short hairpin RNA targeting secreted Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice
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vision/eye
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• corneal injection of a plasmid encoding short hairpin RNA targeting secreted Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice
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homeostasis/metabolism
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• peak contracture during ischemia is greater, diastolic pressure is elevated during reperfusion and recovered only minimally, and the recovery of contractile function is slightly depressed throughout reperfusion, with the rate-pressure product lower at 30 min compared with controls
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muscle
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• in response to chronic hypoxia (10% O2 for 4 wks) homozygotes display a less pronounced RV hypertrophy than hypoxic wild-type mice (41% versus 66% increase in RV/[LV+septum], respectively)
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growth/size/body
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• in response to chronic hypoxia (10% O2 for 4 wks) homozygotes display a less pronounced RV hypertrophy than hypoxic wild-type mice (41% versus 66% increase in RV/[LV+septum], respectively)
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