reproductive system
N |
• both male and female homozygotes are fertile
|
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• in 31% of homozygous mutant testes, clusters of tubules completely lack developing spermatocytes
• however, this abnormal testicular morphology has no impact on male fertility
|
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• mutant testes frequently show less complete filling of the seminiferous tubules, suggesting reduced spermatogenesis
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hematopoietic system
N |
• homozygotes show normal hemopoiesis, both at steady state and in response to several forms of hematopoietic stress
• also, mutants exhibit no abnormalities of mature blood cells or their progenitors
|
small spleen
(
J:71266
)
• homozygotes show normal splenic architecture but a mild reduction in spleen size
|
• reduced spleen size reflects a slightly reduced cellularity without loss of any specific cell subset
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endocrine/exocrine glands
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• in 31% of homozygous mutant testes, clusters of tubules completely lack developing spermatocytes
• however, this abnormal testicular morphology has no impact on male fertility
|
immune system
small spleen
(
J:71266
)
• homozygotes show normal splenic architecture but a mild reduction in spleen size
|
• reduced spleen size reflects a slightly reduced cellularity without loss of any specific cell subset
|
integument
• 56% of male homozygotes display thickening of the epithelial layer of skin, either in discrete patches or in a generalized distribution; only 14% of control C57BL/6 male mice exhibit epithelial thickening
• epithelial thickening is associated with squamous differentiation and some keratin formation; however, mutants show no consistent infiltration of cells in the underlying dermis
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