Phenotypes associated with this allele

• Allele Symbol: Pik3ap1^tm1Kuro
• Allele Name: targeted mutation 1, Tomohiro Kurosaki
• Allele ID: MGI:2178861
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pik3ap1^tm1Kuro/Pik3ap1^tm1Kuro	involves: 129P2/OlaHsd	MGI:3042798

Genotype
MGI:3042798

hm1

• Allelic Composition: Pik3ap1^tm1Kuro/Pik3ap1^tm1Kuro
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell proliferation ( J:84669 )

• after B cell receptor cross-linking, only one further cell division occurs

• splenic B cells display a poor proliferative response to antigen stimulation

abnormal B cell differentiation ( J:75075 )

• IgM^hiIgD^hi to IgM^loIgD^hi transition is largely blocked

decreased B cell number ( J:84669 )

• B220+ cells in the spleen reduced 20-30%

absent B-1a cells ( J:84669 )

• CD5-expressing B1 cells are virtually absent from the peritoneal cavity

decreased follicular B cell number ( J:84669 )

• slight reduction in follicular B cells

decreased pre-B cell number ( J:75075 )

• reduced pre-B cell number in bone marrow

spleen hypoplasia ( J:75075 )

• spleen cell numbers are reduced by 20-30%

decreased immunoglobulin level ( J:75075 )

decreased IgG2b level ( J:75075 )

• slight reduction in IgG2b

decreased IgG3 level ( J:75075 )

• IgG3 titers are reduced in un-immunized mice

decreased IgM level ( J:75075 )

• titers are reduced in un-immunized mice

immune system

decreased B cell proliferation ( J:84669 )

• after B cell receptor cross-linking, only one further cell division occurs

• splenic B cells display a poor proliferative response to antigen stimulation

abnormal B cell differentiation ( J:75075 )

• IgM^hiIgD^hi to IgM^loIgD^hi transition is largely blocked

decreased B cell number ( J:84669 )

• B220+ cells in the spleen reduced 20-30%

absent B-1a cells ( J:84669 )

• CD5-expressing B1 cells are virtually absent from the peritoneal cavity

decreased follicular B cell number ( J:84669 )

• slight reduction in follicular B cells

decreased pre-B cell number ( J:75075 )

• reduced pre-B cell number in bone marrow

spleen hypoplasia ( J:75075 )

• spleen cell numbers are reduced by 20-30%

decreased immunoglobulin level ( J:75075 )

decreased IgG2b level ( J:75075 )

• slight reduction in IgG2b

decreased IgG3 level ( J:75075 )

• IgG3 titers are reduced in un-immunized mice

decreased IgM level ( J:75075 )

• titers are reduced in un-immunized mice

cellular

decreased B cell proliferation ( J:84669 )

• after B cell receptor cross-linking, only one further cell division occurs

• splenic B cells display a poor proliferative response to antigen stimulation