All Phenotypes Mdk<tm1Tmu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdk^tm1Tmu/Mdk^tm1Tmu	129S2-Mdk^tm1Tmu	MGI:3579531
hm2	Mdk^tm1Tmu/Mdk^tm1Tmu	B6.129S2-Mdk^tm1Tmu	MGI:3579532
cx3	Mdk^tm1Tmu/Mdk^tm1Tmu Ptn^tm1Tmu/Ptn^tm1Tmu	B6.129S2-Mdk^tm1Tmu Ptn^tm1Tmu	MGI:6849975
cx4	Mdk^tm1Tmu/Mdk^tm1Tmu Ptn^tm1Tmu/Ptn^tm1Tmu	involves: 129S2/SvPas * C57BL/6J	MGI:3718113

Allelic Composition	Mdk^tm1Tmu/Mdk^tm1Tmu
Genetic Background	129S2-Mdk^tm1Tmu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdk^tm1Tmu mutation (2 available); any Mdk mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:76278 )

• impaired short-term memory using a Y-shaped maze test at 4 weeks but not at 8 weeks

increased anxiety-related response ( J:76278 )

• seen in 4 week old animals but not in 8 week old animals

• less time in the open on an elevated-plus maze

• increased defecation in an open field test

nervous system

abnormal hippocampus development ( J:60666 )

• delayed development of the hippocampus

abnormal dentate gyrus morphology ( J:76278 )

• retarded development

cardiovascular system

abnormal vascular endothelial cell morphology ( J:60666 )

• suppressed on day 14 after carotid ligation

• few inflammatory leukocytes at points of intimal lesions

• lumen circumference significantly increased but not the external elastic lamina

renal/urinary system

tubular nephritis ( J:93637 )

• neutrophil infiltration of the tubulointerstitium slower to develop and faded more rapidly than in control mice

kidney failure ( J:93637 )

• less mortality from kidney failure after cisplatin administration- 90% survival to 7 days as opposed to 30% for controls

• fewer apoptotic cells

• indicators of kidney damage such as BUN, casts, tubular dilation and degeneration all higher than in controls

immune system

tubular nephritis ( J:93637 )

• neutrophil infiltration of the tubulointerstitium slower to develop and faded more rapidly than in control mice

Allelic Composition	Mdk^tm1Tmu/Mdk^tm1Tmu
Genetic Background	B6.129S2-Mdk^tm1Tmu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdk^tm1Tmu mutation (2 available); any Mdk mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage chemotaxis ( J:102069 )

• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased

impaired neutrophil chemotaxis ( J:102069 )

• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

decreased macrophage cell number ( J:102069 )

behavior/neurological

behavior/neurological phenotype ( J:151029 )

N	• mice exhibit normal locomotor activity and acoustic startle reactivity

abnormal social investigation ( J:151029 )

• mice make less frequent contacts, longer times in total contacts, and longer times per one contact compared with wild-type mice

nervous system

decreased prepulse inhibition ( J:151029 )

• adult mice exhibit reduced prepulse inhibition compared with wild-type mice

• however, prepubertal mice and mice treated with haloperidol or clozapine exhibit normal prepulse inhibition

hearing/vestibular/ear

abnormal hearing physiology ( J:110520 )

• mice experience low to moderate levels of auditory deficits

homeostasis/metabolism

abnormal circulating enzyme level ( J:102069 )

• following partial hepatectomy (PH), amino-transferase levels are decreased

decreased dopamine level ( J:151029 )

• in the striatum

abnormal wound healing ( J:88890 )

• less severe adhesions of the intestine after partial hepatectomy (50% as opposed to 100%)

• omental adhesions reduced after peritoneal wall injury

liver/biliary system

decreased hepatocyte number ( J:102069 )

decreased liver weight ( J:102069 )

• one day following partial hepatectomy (PH)

hematopoietic system

abnormal macrophage chemotaxis ( J:102069 )

• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased

impaired neutrophil chemotaxis ( J:102069 )

• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

decreased macrophage cell number ( J:102069 )

cellular

abnormal macrophage chemotaxis ( J:102069 )

• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased

impaired neutrophil chemotaxis ( J:102069 )

• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:151029

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:123392 )

• birth rate of double mutant mice is only one third of the expected rate; following mating of double heterozygotes, only 2.1% are recovered at 1 week after birth versus expected 6.25%

growth/size/body

decreased body weight ( J:123392 )

• at 3-4 weeks of age, body weight is about half of that in wild-type controls

• adult mice weigh 75-80% of age-matched wild-type controls

• however, no significant differences in body weight are observed 1 week after birth

slow postnatal weight gain ( J:123392 )

• both sexes grow much more slowly than wild-type controls from 2 to 4 weeks after birth and the difference in weight gain is maintained to adulthood

• high-calorie diet feeding fails to result in a greater weight gain than ordinary feeding, unlike in wild-type controls

behavior/neurological

decreased locomotor activity ( J:123392 , J:123392 )

	• at 1 month of age, spontaneous locomotive activity is 50-60% of that in wild-type controls; both male and female mice are affected (J:123392)
	• at 3 months of age, spontaneous locomotive activity is still ~80% of that in wild-type males (J:123392) • however, spontaneous locomotive activity is normal in females at 3 months (J:123392)

digestive/alimentary system

abnormal digestive system morphology ( J:123392 )

• all organs of the digestive tract are smaller than those in wild-type controls

abnormal intestinal mucosa morphology ( J:123392 )

• mice exhibit poor growth of the mucosal epithelium in the descending colon, but not in other organs of the digestive tract

abnormal colon morphology ( J:123392 )

• colon shows poor growth, esp. in the mucosal layer of the descending colon

reproductive system

reproductive system phenotype ( J:123392 )

N	• male mice are fertile with normal reproductive capabilities relative to wild-type controls

decreased mature ovarian follicle number ( J:123392 )

• at 4 weeks of age, the number of mature follicles with a single, fused antrum is lower than that in wild-type controls

• however, the total number of follicles (double layered primary follicles and follicles at more advanced stages of maturation) is normal

impaired ovarian folliculogenesis ( J:123392 )

• females exhibit poor maturation of ovarian follicles

small ovary ( J:123392 )

• at 4 weeks of age, ovary size is about 60% of that in wild-type controls

abnormal vagina epithelium morphology ( J:123392 )

• at 10 months of age, the vaginal epithelium is thinner and shows inward projections, indicating vaginal epithelium atrophy

• at 2 months of age, vaginal epithelium thickness is normal, but the multilayered structure of the epithelium is disordered, the nuclear size of the epithelial cells is uneven and condensed chromatins are frequently observed

abnormal vagina orifice morphology ( J:123392 )

• at 10 months of age, 8 of 19 (42%) of mice exhibit vaginal malformations at the opening, unlike single homozygotes

constricted vagina orifice ( J:123392 )

• many mice show narrow vaginas that are frequently divided into two parts

vaginal septum ( J:123392 )

• in females with vaginal malformations, the vaginal lumen is frequently divided into two parts by a wall

vagina atrophy ( J:123392 )

• at 10 months of age, the vaginal epithelium is thinner and shows inward projections, indicating vaginal epithelium atrophy

decreased superovulation rate ( J:123392 )

• following administration of PMS-hCG to 8-10-week-old mice, the number of ovulated ova is significantly lower than that in similarly treated wild-type controls

• however, the % of ova that reach the 2-cell stage after in vitro fertilization is normal

abnormal estrous cycle ( J:123392 )

prolonged diestrus ( J:123392 )

• diestrus period is longer than in wild-type controls; diestrus to proestrus occupies about 4 days in the 6-day estrous cycle

short estrus ( J:123392 )

• estrus period lasts only for 1 day in the 6-day estrous cycle versus 2-3 days in wild-type controls

prolonged proestrus ( J:123392 )

• proestrus period is longer than in wild-type controls; diestrus to proestrus occupies about 4 days in the 6-day estrous cycle

female infertility ( J:123392 )

• 19 of 24 female mice (79%) are sterile

• all females with an abnormal vagina are sterile, without any sign of a plug; on the other hand, 7 of 11 females with a normal vagina are sterile

• superovulation fails to significantly increase the fertility of female mice

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:123392 )

• at 4 weeks of age, the number of mature follicles with a single, fused antrum is lower than that in wild-type controls

• however, the total number of follicles (double layered primary follicles and follicles at more advanced stages of maturation) is normal

impaired ovarian folliculogenesis ( J:123392 )

• females exhibit poor maturation of ovarian follicles

small ovary ( J:123392 )

• at 4 weeks of age, ovary size is about 60% of that in wild-type controls

hearing/vestibular/ear

abnormal hearing physiology ( J:123392 )

• mice exhibit severe auditory deficits

Allelic Composition	Mdk^tm1Tmu/Mdk^tm1Tmu Ptn^tm1Tmu/Ptn^tm1Tmu
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdk^tm1Tmu mutation (2 available); any Mdk mutation (23 available)
Ptn^tm1Tmu mutation (1 available); any Ptn mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:110520 )

hearing/vestibular/ear

abnormal hearing physiology ( J:110520 )

• mice have a severe level of auditory defect

• mice do not respond to low frequency (8-12kHz) sounds and some mice respond to high frequency (16-20kHz) sounds

• however, no defects are observed in the cochlea

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