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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msh5tm1Htr
targeted mutation 1, Hein te Riele
MGI:2179022
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Msh5tm1Htr/Msh5tm1Htr involves: 129P2/OlaHsd * FVB MGI:2664158


Genotype
MGI:2664158
hm1
Allelic
Composition		 Msh5tm1Htr/Msh5tm1Htr
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh5tm1Htr mutation (0 available); any Msh5 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
absent oocytes ( J:53516 )
• absence of oocytes
azoospermia ( J:53516 )
• no spermatozoa in the caudal epididymis
abnormal female meiosis ( J:53516 )
• defective synaptonemal complex formation
arrest of male meiosis ( J:53516 )
• arrest at the zygotene stage, characterized by improper synaptonemal complex formation and frequent non-homologous synapsis
increased male germ cell apoptosis ( J:53516 )
• increased apoptosis of spermatocytes
small ovary ( J:53516 )
• rudimentary appearance
increased granulosa cell tumor incidence ( J:180025 )
• tumors show a consistent pattern of DNA copy number aberrations
decreased testis weight ( J:53516 )
• 70% weight reduction

cellular
absent oocytes ( J:53516 )
• absence of oocytes
azoospermia ( J:53516 )
• no spermatozoa in the caudal epididymis
abnormal female meiosis ( J:53516 )
• defective synaptonemal complex formation
arrest of male meiosis ( J:53516 )
• arrest at the zygotene stage, characterized by improper synaptonemal complex formation and frequent non-homologous synapsis
increased male germ cell apoptosis ( J:53516 )
• increased apoptosis of spermatocytes

endocrine/exocrine glands
small ovary ( J:53516 )
• rudimentary appearance
increased granulosa cell tumor incidence ( J:180025 )
• tumors show a consistent pattern of DNA copy number aberrations
decreased testis weight ( J:53516 )
• 70% weight reduction

neoplasm
increased granulosa cell tumor incidence ( J:180025 )
• tumors show a consistent pattern of DNA copy number aberrations




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory