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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msh4tm1Wed
targeted mutation 1, Winfried Edelmann
MGI:2179034
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Msh4tm1Wed/Msh4tm1Wed involves: 129/Sv * C57BL/6 * SJL MGI:2663946
cx2
 		Msh4tm1Wed/Msh4tm1Wed
Msh5tm1Rak/Msh5tm1Rak 		involves: 129/Sv * C57BL/6 * SJL MGI:2663948


Genotype
MGI:2663946
hm1
Allelic
Composition		 Msh4tm1Wed/Msh4tm1Wed
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh4tm1Wed mutation (0 available); any Msh4 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:62204 )
N
• males showed normal sexual behavior and aggressiveness

cellular
decreased germ cell number ( J:62204 )
• progressive loss of germ cells beginning shortly after birth
azoospermia ( J:62204 )
• absence of spermatozoa in the epididymides
abnormal female meiosis ( J:62204 )
• abnormal chromosomal pairing
abnormal male meiosis ( J:62204 )
• abnormal chromosomal pairing

endocrine/exocrine glands
small ovary ( J:62204 )
• reduced and size and exhibiting aberrant morphology
decreased testis weight ( J:62204 )
• 50% in weight relative to wild-type

reproductive system
decreased germ cell number ( J:62204 )
• progressive loss of germ cells beginning shortly after birth
azoospermia ( J:62204 )
• absence of spermatozoa in the epididymides
abnormal female meiosis ( J:62204 )
• abnormal chromosomal pairing
abnormal male meiosis ( J:62204 )
• abnormal chromosomal pairing
small ovary ( J:62204 )
• reduced and size and exhibiting aberrant morphology
decreased testis weight ( J:62204 )
• 50% in weight relative to wild-type




Genotype
MGI:2663948
cx2
Allelic
Composition		 Msh4tm1Wed/Msh4tm1Wed
Msh5tm1Rak/Msh5tm1Rak
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh4tm1Wed mutation (0 available); any Msh4 mutation (40 available)
Msh5tm1Rak mutation (1 available); any Msh5 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:62204 )
• abnormal chromosomal pairing

cellular
abnormal male meiosis ( J:62204 )
• abnormal chromosomal pairing




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory