About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msh4tm1Wed
targeted mutation 1, Winfried Edelmann
MGI:2179034
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Msh4tm1Wed/Msh4tm1Wed involves: 129/Sv * C57BL/6 * SJL MGI:2663946
cx2
 		Msh4tm1Wed/Msh4tm1Wed
Msh5tm1Rak/Msh5tm1Rak 		involves: 129/Sv * C57BL/6 * SJL MGI:2663948


Genotype
MGI:2663946
hm1
Allelic
Composition		 Msh4tm1Wed/Msh4tm1Wed
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh4tm1Wed mutation (0 available); any Msh4 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:62204 )
N
• males showed normal sexual behavior and aggressiveness

cellular
decreased germ cell number ( J:62204 )
• progressive loss of germ cells beginning shortly after birth
azoospermia ( J:62204 )
• absence of spermatozoa in the epididymides
abnormal female meiosis ( J:62204 )
• abnormal chromosomal pairing
abnormal male meiosis ( J:62204 )
• abnormal chromosomal pairing

endocrine/exocrine glands
small ovary ( J:62204 )
• reduced and size and exhibiting aberrant morphology
decreased testis weight ( J:62204 )
• 50% in weight relative to wild-type

reproductive system
decreased germ cell number ( J:62204 )
• progressive loss of germ cells beginning shortly after birth
azoospermia ( J:62204 )
• absence of spermatozoa in the epididymides
abnormal female meiosis ( J:62204 )
• abnormal chromosomal pairing
abnormal male meiosis ( J:62204 )
• abnormal chromosomal pairing
small ovary ( J:62204 )
• reduced and size and exhibiting aberrant morphology
decreased testis weight ( J:62204 )
• 50% in weight relative to wild-type




Genotype
MGI:2663948
cx2
Allelic
Composition		 Msh4tm1Wed/Msh4tm1Wed
Msh5tm1Rak/Msh5tm1Rak
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh4tm1Wed mutation (0 available); any Msh4 mutation (40 available)
Msh5tm1Rak mutation (1 available); any Msh5 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:62204 )
• abnormal chromosomal pairing

cellular
abnormal male meiosis ( J:62204 )
• abnormal chromosomal pairing




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory