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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sycp3tm1Hoog
targeted mutation 1, Christer Hoog
MGI:2179041
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sycp3tm1Hoog/Sycp3tm1Hoog involves: 129P2/OlaHsd * C57BL/6 MGI:2664131
hm2
 		Sycp3tm1Hoog/Sycp3tm1Hoog involves: 129P2/OlaHsd * C57BL/6NCrl MGI:2664140


Genotype
MGI:2664131
hm1
Allelic
Composition		 Sycp3tm1Hoog/Sycp3tm1Hoog
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sycp3tm1Hoog mutation (0 available); any Sycp3 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:60153 )
• spermatozoa absent from caudal epididymis
abnormal spermatocyte morphology ( J:60153 )
• apoptosis of meiotic spermatocytes
arrest of male meiosis ( J:60153 )
• arrest at zygotene stage of prophase I
• impaired chromosomal synapsis
small seminiferous tubules ( J:60153 )
• 40% reduction in diameter
decreased testis weight ( J:60153 )
• 70% reduction in weight relative to wild-type

endocrine/exocrine glands
small seminiferous tubules ( J:60153 )
• 40% reduction in diameter
decreased testis weight ( J:60153 )
• 70% reduction in weight relative to wild-type

cellular
azoospermia ( J:60153 )
• spermatozoa absent from caudal epididymis
abnormal spermatocyte morphology ( J:60153 )
• apoptosis of meiotic spermatocytes
arrest of male meiosis ( J:60153 )
• arrest at zygotene stage of prophase I
• impaired chromosomal synapsis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
azoospermia DOID:14227 J:60153




Genotype
MGI:2664140
hm2
Allelic
Composition		 Sycp3tm1Hoog/Sycp3tm1Hoog
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sycp3tm1Hoog mutation (0 available); any Sycp3 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female meiosis ( J:76511 )
• defective chromosomal segregation leading to aneuploidy
reduced female fertility ( J:76511 )
• decreased fertility with age
decreased litter size ( J:76511 )
• embryonic loss due to aneuploidy

cellular
abnormal female meiosis ( J:76511 )
• defective chromosomal segregation leading to aneuploidy




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory