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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Skp2tm1Kin
targeted mutation 1, Kei-ichi Nakayama
MGI:2179051
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Skp2tm1Kin/Skp2tm1Kin involves: 129P2/OlaHsd MGI:4941321
hm2
 		Skp2tm1Kin/Skp2tm1Kin involves: 129P2/OlaHsd * C57BL/6 MGI:3036548
cx3
 		Cdkn1btm1Kin/Cdkn1btm1Kin
Skp2tm1Kin/Skp2tm1Kin 		involves: 129P2/OlaHsd * C57BL/6 MGI:3036549


Genotype
MGI:4941321
hm1
Allelic
Composition		 Skp2tm1Kin/Skp2tm1Kin
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skp2tm1Kin mutation (1 available); any Skp2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immunoglobulin V(D)J recombination ( J:168974 )
• thymocytes exhibit aberrant V(D)J recombination compared with wild-type cells

immune system
abnormal immunoglobulin V(D)J recombination ( J:168974 )
• thymocytes exhibit aberrant V(D)J recombination compared with wild-type cells




Genotype
MGI:3036548
hm2
Allelic
Composition		 Skp2tm1Kin/Skp2tm1Kin
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skp2tm1Kin mutation (1 available); any Skp2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased fibroblast apoptosis ( J:62130 )
• rate of apoptosis among embryo fibroblasts is almost doubled
abnormal cell proliferation ( J:62130 )
• growth rate of MEF and T cells in culture is slow
• abnormal amplification of centrosomes in about 38% of cells in culture

endocrine/exocrine glands
abnormal testis morphology ( J:62130 )
• large cells in testes
• cells with enlarged nuclei

growth/size/body
decreased body weight ( J:62130 )
• body weights are about 2/3 wild-type controls
• external body proportions were normal however

liver/biliary system
abnormal hepatocyte morphology ( J:62130 , J:75027 )
• large hepatocytes (J:62130)
• enlarged nuclei in hepatocytes (J:62130)
• after recovery from partial hepatectomy cell and nuclear enlargement of hepatocytes is particularly marked (J:75027)
• DNA content of cells is greatly increased (J:75027)

renal/urinary system
abnormal kidney morphology ( J:62130 )
• large kidney cells
• cells with enlarged nuclei

reproductive system
abnormal testis morphology ( J:62130 )
• large cells in testes
• cells with enlarged nuclei

homeostasis/metabolism
delayed wound healing ( J:74265 )
• cell proliferation in wound recovery is slower than normal




Genotype
MGI:3036549
cx3
Allelic
Composition		 Cdkn1btm1Kin/Cdkn1btm1Kin
Skp2tm1Kin/Skp2tm1Kin
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm1Kin mutation (1 available); any Cdkn1b mutation (26 available)
Skp2tm1Kin mutation (1 available); any Skp2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:74265 )
N
• cell proliferation in wound recovery is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory