All Phenotypes Oprm1<tm1Jep> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Oprm1^tm1Jep
targeted mutation 1, John E Pintar
MGI:2179052

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm1Jep/Oprm1^tm1Jep	B6.129S-Oprm1^tm1Jep	MGI:4358701
hm2	Oprm1^tm1Jep/Oprm1^tm1Jep	involves: 129S/SvEv	MGI:4358621
ht3	Oprm1^tm1Jep/Oprm1⁺	B6.129S-Oprm1^tm1Jep	MGI:4358702
ht4	Oprm1^tm1Jep/Oprm1⁺	involves: 129S/SvEv	MGI:4358622
cx5	Oprd1^tm1Jep/Oprd1^tm1Jep Oprm1^tm1Jep/Oprm1^tm1Jep Oprm1^tm1Jep/Oprm1^tm1Jep	involves: 129S/SvEv * 129S2/SvPas	MGI:4358720
cx6	Arrb2^tm1Rjl/Arrb2^tm1Rjl Oprm1^tm1Jep/Oprm1^tm1Jep Tg(Th-Oprm1)4Jtw/0	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4355146
cx7	Oprm1^tm1Jep/Oprm1^tm1Jep Tg(Th-Oprm1)4Jtw/0	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:4355145

Allelic Composition	Oprm1^tm1Jep/Oprm1^tm1Jep
Genetic Background	B6.129S-Oprm1^tm1Jep

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced behavioral response to addictive substance ( J:101294 )

• following treatment with amphetamine, mice exhibit a greater increase in locomotor activity compared with similarly treated wild-type mice

abnormal operant conditioning behavior ( J:101294 )

• 2.5 hours before food access, mice exhibit a reduced increased in running wheel activity prior to food access (food anticipitory behavior) compared with similarly treated wild-type mice

• during the 3 hours feeding period, mice exhibit a lower decrease in running wheel activity compared with similarly treated wild-type mice

induced hyperactivity ( J:101294 )

• following treatment with amphetamine, mice exhibit a greater increase in locomotor activity compared with similarly treated wild-type mice

nervous system

impaired ability to fire action potentials ( J:101066 )

• midbrain dopamine neurons exhibit lower firing rates and non-bursting activity compared to in wild-type mice with fewer neurons exhibiting fast firing rates

• unlike in wild-type mice, one third of neurons display no bursting at all

• however, the quality of bursting size, burst duration, and frequency of pikes within bursts are normal

adipose tissue

increased total body fat amount ( J:147786 )

• fat tissue is increased 73% compared to in wild-type mice

increased percent body fat/body weight ( J:147786 )

• mice exhibit a 5% increased in fat as a percentage of body composition compared with wild-type mice

homeostasis/metabolism

increased insulin secretion ( J:147786 )

• mice exhibit a 50% increase in pancreas insulin content compared with wild-type mice

• glucose- and tolbutamide-mediated insulin secretion is increased compared to in wild-type islets

increased circulating insulin level ( J:147786 )

• after glucose challenge

improved glucose tolerance ( J:147786 )

• mice exhibit improved glucose tolerance that does not decrease with age

growth/size/body

increased pancreas weight ( J:147786 )

abnormal lean body mass ( J:147786 )

• while mice exhibit a 11% increase in lean tissue this results is a 5% decrease in lean tissue as a percent of whole body composition compared with wild-type mice

increased body weight ( J:147786 )

• mice exhibit increased body weight compared with wild-type mice except at birth and during the weaning period (2 to 4 weeks)

endocrine/exocrine glands

enlarged pancreatic islets ( J:147786 )

increased pancreas weight ( J:147786 )

increased insulin secretion ( J:147786 )

• mice exhibit a 50% increase in pancreas insulin content compared with wild-type mice

• glucose- and tolbutamide-mediated insulin secretion is increased compared to in wild-type islets

Allelic Composition	Oprm1^tm1Jep/Oprm1^tm1Jep
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:52952 , J:65217 )

• in a tail flick assay, mice treated with morphine, methadone, or DAMGO display nearly no analgesic response unlike in similarly treated wild-type mice (J:52952)

• however, analgesic response to U50,488H, naloxone benzoylhydrazone (NalBzoH), morphine-6beta-glucuronide (M6G), heroine, 6-acetyl-morphine, and D-Penicillamine(2,5)-enkephalin (DPDPE) is normal (J:52952)

• morphine analgesic response is abolished unlike in wild-type mice (J:65217)

enhanced behavioral response to anesthetic ( J:65217 )

• improgan analgesic response is enhanced in female mice compared to in wild-type mice

• however, improgan analgesia in males is normal

impaired behavioral response to anesthetic ( J:52952 , J:65217 )

• in a tail flick assay, mice treated with morphine, methadone, or DAMGO display nearly no analgesic response unlike in similarly treated wild-type mice (J:52952)

• morphine analgesic response is abolished unlike in wild-type mice (J:65217)

Allelic Composition	Oprm1^tm1Jep/Oprm1⁺
Genetic Background	B6.129S-Oprm1^tm1Jep

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced behavioral response to addictive substance ( J:101294 )

• following treatment with amphetamine, mice exhibit a greater increase in locomotor activity compared with similarly treated wild-type mice

abnormal operant conditioning behavior ( J:101294 )

• during the 3 hours feeding period, mice exhibit a lower decrease running wheel activity compared with similarly treated wild-type mice

induced hyperactivity ( J:101294 )

• following treatment with amphetamine, mice exhibit a greater increase in locomotor activity compared with similarly treated wild-type mice

Allelic Composition	Oprm1^tm1Jep/Oprm1⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:52952 , J:65217 )

• in a tail flick assay, mice exhibit an intermediate analgesic response following morphine, methadone, or DAMGO treatment compared with wild-type and homozygous mice (J:52952)

• morphine analgesic response is attenuated compared to in wild-type mice (J:65217)

enhanced behavioral response to anesthetic ( J:65217 )

• improgan analgesic response is enhanced in female mice compared to in wild-type mice

• however, improgan analgesia in males is normal

impaired behavioral response to anesthetic ( J:52952 , J:65217 )

• in a tail flick assay, mice exhibit an intermediate analgesic response following morphine, methadone, or DAMGO treatment compared with wild-type and homozygous mice (J:52952)

• morphine analgesic response is attenuated compared to in wild-type mice (J:65217)

Allelic Composition	Oprd1^tm1Jep/Oprd1^tm1Jep Oprm1^tm1Jep/Oprm1^tm1Jep Oprm1^tm1Jep/Oprm1^tm1Jep
Genetic Background	involves: 129S/SvEv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprd1^tm1Jep mutation (0 available); any Oprd1 mutation (30 available)
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:124042 )

N	• mice exhibit normal nociception prior to opioid infusion

impaired behavioral response to morphine ( J:124042 )

• unlike in wild-type mice, mice exhibit decreased tail-withdrawal latencies demonstrating the abolishment of opioid analgesic responses to acute doses of morphine and oxymorphone

• infusion of morphine results in a decrease in tail withdrawal latency relative to baseline after 2 days unlike similarly treated wild-type mice that display an increase on the first two days and a decrease on days 4 through 7

• infusion of oxymorphone results in reduced tail withdrawal latency compared to baseline at 4 days unlike in similarly treated wild-type mice that exhibit an increase in latency within the first 4 days and a decrease on days 8 through 10

• NMDA receptor blockage with MK-801 does not reverse opioid hyperalgesia unlike in similarly treated wild-type mice

impaired behavioral response to anesthetic ( J:124042 )

• unlike in wild-type mice, mice exhibit decreased tail-withdrawal latencies demonstrating the abolishment of opioid analgesic responses to acute doses of morphine and oxymorphone

• NMDA receptor blockage with MK-801 does not reverse opioid hyperalgesia unlike in similarly treated wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:124042 )

• NMDA receptor blockage with MK-801 does not reverse opioid hyperalgesia unlike in similarly treated wild-type mice

Allelic Composition	Arrb2^tm1Rjl/Arrb2^tm1Rjl Oprm1^tm1Jep/Oprm1^tm1Jep Tg(Th-Oprm1)4Jtw/0
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arrb2^tm1Rjl mutation (2 available); any Arrb2 mutation (27 available)
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (54 available)
Tg(Th-Oprm1)4Jtw mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:151536 )

N	• desensitization and internalization of opioid receptors after met-enkephalin treatment is similar to that in controls

Allelic Composition	Oprm1^tm1Jep/Oprm1^tm1Jep Tg(Th-Oprm1)4Jtw/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (54 available)
Tg(Th-Oprm1)4Jtw mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:151536 )

• maximum hyperpolarization of neurons induced by met-enkephalin (ME) is similar to that seen in wild-type and transgenic wild-type opioid receptor mutant animals; the EC₅₀ for ME is 50% greater than the transgene-only mutants

• desensitization by ME and recovery of desensitization of receptors is similar to wild-type and transgene-only controls

• desensitization and internalization of the mu-opioid receptor (MOR) in response to various MOR agonists is not different in mutants and controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24