Phenotypes associated with this allele

• Allele Symbol: Grin2b^tm2Mim
• Allele Name: targeted mutation 2, Masayoshi Mishina
• Allele ID: MGI:2179059
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2b^tm2Mim/Grin2b^tm2Mim	involves: C57BL/6 * CBA	MGI:3845824

Genotype
MGI:3845824

hm1

• Allelic Composition: Grin2b^tm2Mim/Grin2b^tm2Mim
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:76019 )

• no homozygotes survive past weaning

• numbers of homozygotes are normal at birth

• homozygotes are all dead at 3 days of age

nervous system

abnormal CNS synaptic transmission ( J:76019 )

• NMDA channel mediated synaptic response to fiber volley amplitudes is reduced

abnormal excitatory postsynaptic potential ( J:76019 )

• contribution of NMDA receptor EPSP relative to non NMDA receptor contributions in the CA1 region of the hippocampus is considerably lower than for controls

• EPSP amplitude is 79.6% of control amplitudes 30 minutes after prolonged low frequency stimulation of afferent fibers

abnormal long-term depression ( J:76019 )

• prolonged low frequency stimulation of afferent fibers produces a very robust long-term depression in CA1

• excitatory post synaptic potential amplitude is 79.6% of control amplitudes 30 minutes after stimulation