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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ripk1tm1Led
targeted mutation 1, Philip Leder
MGI:2179109
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ripk1tm1Led/Ripk1tm1Led involves: 129S6/SvEvTac MGI:3038877
cx2
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Ripk1tm1Led/Ripk1tm1Led
Xiaptm1Vdr/Xiaptm1Vdr
involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6 MGI:5319382
cx3
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Ripk1tm1Led/Ripk1+
Xiaptm1Vdr/Xiaptm1Vdr
involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6 MGI:5319383
cx4
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Ripk1tm1Led/Ripk1tm1Led
involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL MGI:5319380
cx5
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Ripk1tm1Led/Ripk1+
involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL MGI:5319385


Genotype
MGI:3038877
hm1
Allelic
Composition
Ripk1tm1Led/Ripk1tm1Led
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk1tm1Led mutation (0 available); any Ripk1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygotes survived beyond 3 days after birth

adipose tissue
• tissue damage and granulocyte infiltration

growth/size/body
• 2-3 days after birth homozygotes weighed 1/3 to 1/2 normal

hematopoietic system
• numerous apoptotic bodies found throughout the thymus
• reduced thymocyte viability at E18
• while WBC counts are normal, there is an increased percentage of myeloid cells and a decrease in peripheral blood lymphocytes

homeostasis/metabolism
• edema is seen in the neck, axillary, and inguinal areas

immune system
• while WBC counts are normal, there is an increased percentage of myeloid cells and a decrease in peripheral blood lymphocytes
• numerous apoptotic bodies found throughout the thymus
• reduced thymocyte viability at E18
• lacked normal architecture and were edematous, necrotic and infiltrated with granulocytes

integument
• tissue damage and granulocyte infiltration

endocrine/exocrine glands
• numerous apoptotic bodies found throughout the thymus
• reduced thymocyte viability at E18




Genotype
MGI:5319382
cx2
Allelic
Composition
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Ripk1tm1Led/Ripk1tm1Led
Xiaptm1Vdr/Xiaptm1Vdr
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Ripk1tm1Led mutation (0 available); any Ripk1 mutation (33 available)
Xiaptm1Vdr mutation (0 available); any Xiap mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5319383
cx3
Allelic
Composition
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Ripk1tm1Led/Ripk1+
Xiaptm1Vdr/Xiaptm1Vdr
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Ripk1tm1Led mutation (0 available); any Ripk1 mutation (33 available)
Xiaptm1Vdr mutation (0 available); any Xiap mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die within 10 weeks of birth
• however, two mice survive for 6 weeks

growth/size/body
• two surviving mice




Genotype
MGI:5319380
cx4
Allelic
Composition
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Ripk1tm1Led/Ripk1tm1Led
Genetic
Background
involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3tm1.1Rbr mutation (0 available); any Birc3 mutation (32 available)
Ripk1tm1Led mutation (0 available); any Ripk1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5319385
cx5
Allelic
Composition
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Ripk1tm1Led/Ripk1+
Genetic
Background
involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3tm1.1Rbr mutation (0 available); any Birc3 mutation (32 available)
Ripk1tm1Led mutation (0 available); any Ripk1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory