mortality/aging
• no homozygotes survived beyond 3 days after birth
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adipose tissue
• tissue damage and granulocyte infiltration
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growth/size/body
• 2-3 days after birth homozygotes weighed 1/3 to 1/2 normal
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hematopoietic system
• numerous apoptotic bodies found throughout the thymus
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• reduced thymocyte viability at E18
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• while WBC counts are normal, there is an increased percentage of myeloid cells and a decrease in peripheral blood lymphocytes
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homeostasis/metabolism
immune system
• while WBC counts are normal, there is an increased percentage of myeloid cells and a decrease in peripheral blood lymphocytes
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• numerous apoptotic bodies found throughout the thymus
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• reduced thymocyte viability at E18
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• lacked normal architecture and were edematous, necrotic and infiltrated with granulocytes
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integument
• tissue damage and granulocyte infiltration
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endocrine/exocrine glands
• numerous apoptotic bodies found throughout the thymus
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• reduced thymocyte viability at E18
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