Analysis Tools
mortality/aging
|
• at 15 months, only 27% of mice are alive compared to 67% of wild-type mice
|
immune system
|
• at 15 months, mice exhibit splenomegaly with spleen size 2 to 5 times greater than that of wild-type mice
|
|
• at week 8 to 12, spleen weight is increased 2-fold (1445+/-250 mg) relative to in wild-type mice (668+/-108 mg) and continues to increase at 15 months (3340+/-540 mg compared to 722+/-125 mg in wild-type mice)
|
|
• the fraction of mature (CD4+ and, especially, CD8+) thymocytes in the thymus is increased with a decreased in immature double positive thymocytes
|
|
• there is an increase in the number of CD8+ T cells relative to CD4+ T cells (CD4+/CD8+ ratio: 0.79+/-0.1 compared to 1.43+/-0.3 in wild-type mice)
• however, the T to B cells ratio is normal
|
|
• at 3 to 4 weeks and at 15 months, the number of CD44hiCD69- memory T cells is increased
|
|
• at 15 months, mice display white pulp hyperplasia and increased sinusoidal cellularity
|
|
• in response to IL-2 treatment, effector/memory cell (CD44hiCD69-) T cell proliferation is increased relative to in wild-type mice by 2 times at weeks 8 to 12, and 13 times at 15 months
• T cell proliferation stimulated by CD3 antibody is increased compared to in stimulated wild-type mice and is more prominent at suboptimal CD3 antibody concentrations
|
|
• at 15 months, mice exhibit features of autoimmune disease including inflammatory infiltrate, adnormal accumulation of effector/memory T cells, and double stranded DNA antibodies
|
|
• the amount of double stranded DNA antibodies is increased relative to in wild-type mice and corresponds to the severity of organ damage
|
|
• at 15 months, mice exhibit features of autoimmune disease
• in elderly mice, increased mononuclear infiltrate is observed in the lung, kidney and liver
|
|
• in elderly mice, inflammatory infiltrate accumulates in the liver and perivascular infiltrates are observed
|
|
• elderly mice exhibit membranoproliferative glomerulonephritis that is focal and of moderate intensity
• affected glomeruli are enlarged with a thickened basement membrane and contain perivascular aggregates of inflammatory infiltrate and immune complex deposition
|
|
• in elderly mice, inflammatory infiltrate accumulates in the lung
|
liver/biliary system
|
• in elderly mice, inflammatory infiltrate accumulates in the liver and perivascular infiltrates are observed
|
renal/urinary system
|
• elderly mice exhibit membranoproliferative glomerulonephritis that is focal and of moderate intensity
• affected glomeruli are enlarged with a thickened basement membrane and contain perivascular aggregates of inflammatory infiltrate and immune complex deposition
|
|
• affected glomeruli display a thickened basement membrane
|
|
• affected glomeruli are enlarged
|
respiratory system
|
• in elderly mice, inflammatory infiltrate accumulates in the lung
|
hematopoietic system
|
• in response to IL-2 treatment, effector/memory cell (CD44hiCD69-) T cell proliferation is increased relative to in wild-type mice by 2 times at weeks 8 to 12, and 13 times at 15 months
• T cell proliferation stimulated by CD3 antibody is increased compared to in stimulated wild-type mice and is more prominent at suboptimal CD3 antibody concentrations
|
|
• at 15 months, mice exhibit splenomegaly with spleen size 2 to 5 times greater than that of wild-type mice
|
|
• at week 8 to 12, spleen weight is increased 2-fold (1445+/-250 mg) relative to in wild-type mice (668+/-108 mg) and continues to increase at 15 months (3340+/-540 mg compared to 722+/-125 mg in wild-type mice)
|
|
• the fraction of mature (CD4+ and, especially, CD8+) thymocytes in the thymus is increased with a decreased in immature double positive thymocytes
|
|
• there is an increase in the number of CD8+ T cells relative to CD4+ T cells (CD4+/CD8+ ratio: 0.79+/-0.1 compared to 1.43+/-0.3 in wild-type mice)
• however, the T to B cells ratio is normal
|
|
• at 3 to 4 weeks and at 15 months, the number of CD44hiCD69- memory T cells is increased
|
|
• at 15 months, mice display white pulp hyperplasia and increased sinusoidal cellularity
|
cellular
|
• adenovirus-Myc fails to induce S phase as it does in wild-type mouse embryonic fibroblasts
|
|
• cell death induced by Myc expression in primary fibroblast cells is somewhat less efficient than in wild-type primary fibroblast
|
|
• in response to IL-2 treatment, effector/memory cell (CD44hiCD69-) T cell proliferation is increased relative to in wild-type mice by 2 times at weeks 8 to 12, and 13 times at 15 months
• T cell proliferation stimulated by CD3 antibody is increased compared to in stimulated wild-type mice and is more prominent at suboptimal CD3 antibody concentrations
|
integument
|
• elderly mice exhibit considerable hair loss
|
|
• elderly mice exhibit skin wounds
|
reddish skin
(
J:76318
)
|
• elderly mice exhibit erythema affecting the head and neck
|
growth/size/body
|
• at 15 months, mice exhibit splenomegaly with spleen size 2 to 5 times greater than that of wild-type mice
|
|
• at week 8 to 12, spleen weight is increased 2-fold (1445+/-250 mg) relative to in wild-type mice (668+/-108 mg) and continues to increase at 15 months (3340+/-540 mg compared to 722+/-125 mg in wild-type mice)
|
