Analysis Tools
mortality/aging
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• death between 0.5 and 1 year of age probably secondary to overall poor condition
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• only 10% of expected numbers of homozygotes found at birth
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behavior/neurological
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• excessive washing activities
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• involved head, ears, and neckline
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• jumping (n=3)
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cardiovascular system
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• poor vascularization
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craniofacial
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• cleft lip is frequently seen in E13.5 to 19.5 embryos
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• one instance of cleft secondary palate due to imperfect closure of the palatine shelves of the maxilla
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eyelid edema
(
J:74288
)
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• swelling of eyelids
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digestive/alimentary system
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• one instance of cleft secondary palate due to imperfect closure of the palatine shelves of the maxilla
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• swollen anus
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• soft oily feces
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embryo
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• vascular basement membrane was thicker and darker than normal
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• swollen trophoblastic cells
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endocrine/exocrine glands
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• clusters of detatched sertioli cells found in the seminiferous tubules
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• small diameter and with an excess of interstitial tissue
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small testis
(
J:74288
)
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growth/size/body
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• cleft lip is frequently seen in E13.5 to 19.5 embryos
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• one instance of cleft secondary palate due to imperfect closure of the palatine shelves of the maxilla
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eyelid edema
(
J:74288
)
|
• swelling of eyelids
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• newborns much smaller than normal at birth and remain so throughout life
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• growth retardation between E13.5 and 19.5
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immune system
blepharitis
(
J:74288
)
reproductive system
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• clusters of detatched sertioli cells found in the seminiferous tubules
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• small diameter and with an excess of interstitial tissue
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small testis
(
J:74288
)
|
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• absent by day 15
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• reduced female fertility although follicular development normal
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• reduced female fertility although follicular development normal
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• males are sterile
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vision/eye
blepharitis
(
J:74288
)
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• animals avoid opening their eyes widely
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eyelid edema
(
J:74288
)
|
• swelling of eyelids
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• eyelids were not closed and fused as is normal between E15.5 and 19.5
• all other eye dysmorphology did not appear until 7 to 10 days of age
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eye opacity
(
J:74288
)
|
• some animals had "opaque eyes" but no further details were given
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• excessive eye fluid starting at 7 to 10 days of age
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adipose tissue
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• adults lack fatty tissue
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homeostasis/metabolism
eyelid edema
(
J:74288
)
|
• swelling of eyelids
|
integument
