All Phenotypes Ppm1d<tm1Lad> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppm1d^tm1Lad/Ppm1d^tm1Lad	involves: 129S7/SvEvBrd	MGI:5500174
hm2	Ppm1d^tm1Lad/Ppm1d^tm1Lad	involves: 129S7/SvEvBrd * C57BL/6	MGI:2672136
cx3	Atm^tm1Awb/Atm^tm1Awb Ppm1d^tm1Lad/Ppm1d^tm1Lad Tg(IghMyc)22Bri/0	involves: 129 * C57BL * FVB/N * SJL	MGI:3710183
cx4	Cdkn2a^tm1Cjs/Cdkn2a⁺ Ppm1d^tm1Lad/Ppm1d^tm1Lad Tg(IghMyc)22Bri/0	involves: 129 * C57BL * FVB/N * SJL	MGI:3710182
cx5	Ppm1d^tm1Lad/Ppm1d^tm1Lad Tg(IghMyc)22Bri/0 Trp53^tm1Brd/Trp53⁺	involves: 129 * C57BL * FVB/N * SJL	MGI:3710184
cx6	Mapk14^tm1.1Dvb/Mapk14⁺ Ppm1d^tm1Lad/Ppm1d^tm1Lad	involves: 129S7/SvEvBrd * C57BL/6	MGI:5500175
cx7	Ppm1d^tm1Lad/Ppm1d^tm1Lad Tg(IghMyc)22Bri/0	involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL	MGI:3710180
cx8	Ppm1d^tm1Lad/Ppm1d⁺ Tg(IghMyc)22Bri/0	involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL	MGI:3710179
cx9	Mapk14^tm1.1Dvb/Mapk14⁺ Ppm1d^tm1Lad/Ppm1d^tm1Lad Tg(IghMyc)22Bri/0	involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL	MGI:3710181

Allelic Composition	Ppm1d^tm1Lad/Ppm1d^tm1Lad
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1d^tm1Lad mutation (1 available); any Ppm1d mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased pancreatic beta cell proliferation ( J:151980 )

• pancreatic islet proliferation is decreased in 4-6 month old mice, however, the phenotype is reversed in double mutant Ppm1d^tm1Lad Mapk14^tm1.1Dvb mice

endocrine/exocrine glands

decreased pancreatic beta cell proliferation ( J:151980 )

• pancreatic islet proliferation is decreased in 4-6 month old mice, however, the phenotype is reversed in double mutant Ppm1d^tm1Lad Mapk14^tm1.1Dvb mice

homeostasis/metabolism

impaired glucose tolerance ( J:151980 )

• mice exhibit impaired glucose tolerance as measured by IPGTT

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:74284 )

• only 3 of 20 males survived to 2 years of age

• majority of female null littermates survived to this point, having a similar survival rate as wild-type controls

prenatal lethality, incomplete penetrance ( J:74284 )

• fewer than expected number of homozygous mutant pups at birth

• fewer male pups than female, indicating possible selection against male embryos during gestation

• analysis of midgestation embryos failed to show any obvious developmental abnormalities in null mice, authors suggest this may be the result of a portion of the males succumbing to early embryonic defects

cellular

oligozoospermia ( J:74284 )

• reduced numbers produced over time, authors suggest as a result of inability to maintain spermatogenesis

decreased B cell proliferation ( J:74284 )

• stimulation with LPS resulted in less robust response than wild-type controls

decreased T cell proliferation ( J:74284 )

• stimulation with either anti-CD3 and anti-CD28 or PHA resulted in reduced response compared to wild-type controls

endocrine/exocrine glands

small thymus ( J:74284 )

• some older animals showed reduced thymus size and loss of normal architecture

seminiferous tubule degeneration ( J:74284 )

• extensive vacuolization, loss of normal cellular architecture, and sometimes, absence of mature spermatozoa

small testis ( J:74284 )

growth/size/body

decreased body size ( J:74284 )

• males only

enlarged spleen ( J:74284 )

spleen hyperplasia ( J:74284 )

• myeloid and plasmactyic hyperplasia

• hyperplasia was sometimes accompanied by loss of normal splenic architecture

hematopoietic system

decreased B cell proliferation ( J:74284 )

• stimulation with LPS resulted in less robust response than wild-type controls

decreased T cell proliferation ( J:74284 )

• stimulation with either anti-CD3 and anti-CD28 or PHA resulted in reduced response compared to wild-type controls

small thymus ( J:74284 )

• some older animals showed reduced thymus size and loss of normal architecture

enlarged spleen ( J:74284 )

spleen hyperplasia ( J:74284 )

• myeloid and plasmactyic hyperplasia

• hyperplasia was sometimes accompanied by loss of normal splenic architecture

myeloid hyperplasia ( J:74284 )

increased CD4-positive, alpha-beta T cell number ( J:74284 )

• increased numbers

decreased CD8-positive, alpha-beta T cell number ( J:74284 )

• decreased numbers

immune system

decreased B cell proliferation ( J:74284 )

• stimulation with LPS resulted in less robust response than wild-type controls

decreased T cell proliferation ( J:74284 )

• stimulation with either anti-CD3 and anti-CD28 or PHA resulted in reduced response compared to wild-type controls

small thymus ( J:74284 )

• some older animals showed reduced thymus size and loss of normal architecture

enlarged spleen ( J:74284 )

spleen hyperplasia ( J:74284 )

• myeloid and plasmactyic hyperplasia

• hyperplasia was sometimes accompanied by loss of normal splenic architecture

myeloid hyperplasia ( J:74284 )

increased CD4-positive, alpha-beta T cell number ( J:74284 )

• increased numbers

decreased CD8-positive, alpha-beta T cell number ( J:74284 )

• decreased numbers

lymphoid hyperplasia ( J:74284 )

• lymph nodes hyperplastic, with infiltration by macrophages, neutrophils, and eosinophils

chronic inflammation ( J:74284 )

• organs of older animals showed increased inflammation, particularly in those animals with skin lesions

increased susceptibility to Orthomyxoviridae infection ( J:74284 )

• increased mortality after infection with mouse-adapted pathogenic influenza virus

reproductive system

oligozoospermia ( J:74284 )

• reduced numbers produced over time, authors suggest as a result of inability to maintain spermatogenesis

seminiferous tubule degeneration ( J:74284 )

• extensive vacuolization, loss of normal cellular architecture, and sometimes, absence of mature spermatozoa

small testis ( J:74284 )

abnormal epididymis morphology ( J:74284 )

• atrophic

• irregular tubules, with abnormal architecture

male infertility ( J:74284 )

• few males succeeded in producing offspring

integument

skin lesions ( J:74284 )

• 5% of animals showed ulcerated skin lesions

• 25% of older mice had fluid-filled neck abscesses

Allelic Composition	Atm^tm1Awb/Atm^tm1Awb Ppm1d^tm1Lad/Ppm1d^tm1Lad Tg(IghMyc)22Bri/0
Genetic Background	involves: 129 * C57BL * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Awb mutation (7 available); any Atm mutation (170 available)
Ppm1d^tm1Lad mutation (1 available); any Ppm1d mutation (31 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:120284 )

• the median lifespan of 69 days

neoplasm

increased tumor incidence ( J:120284 )

• based on median survival time, mice carrying double Atm^tm1Awb allele were no more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d⁺ allele

Allelic Composition	Cdkn2a^tm1Cjs/Cdkn2a⁺ Ppm1d^tm1Lad/Ppm1d^tm1Lad Tg(IghMyc)22Bri/0
Genetic Background	involves: 129 * C57BL * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Cjs mutation (7 available); any Cdkn2a mutation (67 available)
Ppm1d^tm1Lad mutation (1 available); any Ppm1d mutation (31 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:120284 )

• the median lifespan of >130 days

neoplasm

decreased tumor incidence ( J:120284 )

• similar to mice carrying double Ppm1d^tm1Lad allele without Cdkn2a^tm1Cjs allele, based on increased median survival time, mice carrying single Cdkn2a^tm1Cjs allele were considerably more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d⁺ allele

Allelic Composition	Ppm1d^tm1Lad/Ppm1d^tm1Lad Tg(IghMyc)22Bri/0 Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129 * C57BL * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1d^tm1Lad mutation (1 available); any Ppm1d mutation (31 available)
Tg(IghMyc)22Bri mutation (1 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:120284 )

• the median lifespan of 31 days

neoplasm

increased tumor incidence ( J:120284 )

• based on median survival time, mice carrying single Trp53^tm1Brd allele were no more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d⁺ allele

Allelic Composition	Mapk14^tm1.1Dvb/Mapk14⁺ Ppm1d^tm1Lad/Ppm1d^tm1Lad
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14^tm1.1Dvb mutation (1 available); any Mapk14 mutation (43 available)
Ppm1d^tm1Lad mutation (1 available); any Ppm1d mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:151980 )

• double mutant Ppm1d^tm1Lad Mapk14^tm1.1Dvb mice exhibit pancreatic islet proliferation similar to wild-type, correcting the phenotype observed in Ppm1d^tm1Lad mutant mice

• double mutant Ppm1d^tm1Lad Mapk14^tm1.1Dvb mice do not exhibit impaired glucose tolerance, correcting the phenotype observed in Ppm1d^tm1Lad/ mutant mice

Allelic Composition	Ppm1d^tm1Lad/Ppm1d^tm1Lad Tg(IghMyc)22Bri/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1d^tm1Lad mutation (1 available); any Ppm1d mutation (31 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:120284 )

• the median lifespan of 138 days

neoplasm

decreased tumor incidence ( J:120284 )

• mice carrying double Ppm1d^tm1Lad allele were considerably more resistant to tumor formation induced by myc than wild-type transgenic litter mates based on increased median survival time by about 60 days

Allelic Composition	Ppm1d^tm1Lad/Ppm1d⁺ Tg(IghMyc)22Bri/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1d^tm1Lad mutation (1 available); any Ppm1d mutation (31 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:120284 )

• the median lifespan of 107 days

neoplasm

decreased tumor incidence ( J:120284 )

• mice carrying a single Ppm1d^tm1Lad allele were considerably more resistant to tumor formation induced by myc than wild-type transgenic litter mates based on increased median survival time by about 30 days

Allelic Composition	Mapk14^tm1.1Dvb/Mapk14⁺ Ppm1d^tm1Lad/Ppm1d^tm1Lad Tg(IghMyc)22Bri/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:120284 )

• the median lifespan of 130 days

neoplasm

decreased tumor incidence ( J:120284 )

• similar to mice carrying double Ppm1d^tm1Lad allele without Mapk14^tm1Dvb allele, based on increased median survival time, mice carrying single Mapk14^tm1Dvb allele were considerably more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d⁺ allele

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