Phenotypes associated with this allele

• Allele Symbol: Top2b^tm1Jcw
• Allele Name: targeted mutation 1, James C Wang
• Allele ID: MGI:2179201
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Top2b^tm1Jcw/Top2b^tm1Jcw	involves: 129S1/Sv * 129X1/SvJ	MGI:2179239

Genotype
MGI:2179239

hm1

• Allelic Composition: Top2b^tm1Jcw/Top2b^tm1Jcw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:75958 )

• animals die shortly after birth

behavior/neurological

paralysis ( J:75958 )

• neonates exhibit neither spontaneous nor tactile stimulated movement

embryo

decreased embryo size ( J:75958 )

• animals are approximately 65% of the size of wild-type or heterozygous littermates

growth/size/body

decreased embryo size ( J:75958 )

• animals are approximately 65% of the size of wild-type or heterozygous littermates

respiratory system

respiratory failure ( J:75958 )

• neonates do not breathe

skeleton

kyphosis ( J:75958 )

• abnormal curvature of the spine; embryos and neonates have a more pronounced curled appearance

nervous system

abnormal innervation pattern to muscle ( J:75958 )

• failure of motor neuron innervation; axons reach muscles but fail to grow or branch into diaphragm or limb muscles

abnormal motor neuron innervation pattern ( J:75958 )