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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tff3tm1Dkpy
targeted mutation 1, Daniel K Podolsky
MGI:2179219
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tff3tm1Dkpy/Tff3tm1Dkpy involves: 129S4/SvJae MGI:3029147


Genotype
MGI:3029147
hm1
Allelic
Composition		 Tff3tm1Dkpy/Tff3tm1Dkpy
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tff3tm1Dkpy mutation (1 available); any Tff3 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal epithelium morphology ( J:35882 )
• impaired physiological migration of epithelium to mucosal surface
increased susceptibility to induced colitis ( J:35882 )
• increased development of colitis (colon ulceration, abscesses, and hemorrhage) after dextran sulfate sodium (DSS) administration

immune system
increased susceptibility to induced colitis ( J:35882 )
• increased development of colitis (colon ulceration, abscesses, and hemorrhage) after dextran sulfate sodium (DSS) administration

homeostasis/metabolism
increased susceptibility to injury ( J:35882 )
• increased development of colitis (colon ulceration, abscesses, and hemorrhage) after dextran sulfate sodium (DSS) administration
• increased development of bloody diarrhea and death after (DSS) administration
• increased weight loss after (DSS) administration




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory