Phenotypes associated with this allele

• Allele Symbol: Tff1^tm1Mrio
• Allele Name: targeted mutation 1, Marie-Christine Rio
• Allele ID: MGI:2179220
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tff1^tm1Mrio/Tff1^tm1Mrio	involves: 129S2/SvPas	MGI:5433072
hm2	Tff1^tm1Mrio/Tff1^tm1Mrio	involves: 129S2/SvPas * 129X1/SvJ	MGI:3028979

Genotype
MGI:5433072

hm1

• Allelic Composition: Tff1^tm1Mrio/Tff1^tm1Mrio
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased stomach tumor incidence ( J:84201 )

• stomach shows nodularity externally and polypoid, firm lesions intramucosally in a circumferential manner in the distal stomach

• mutants develop gastric tumors

digestive/alimentary system

abnormal stomach mucosa morphology ( J:84201 )

• mutants exhibit dysplastic lesions in the antral mucosa; dysplastic glands are lined by epithelial cells that, in contrast to controls, are crowded and overlapping, and whose nuclei show hyperchromasia, irregular nuclear contours, and pleomorphism

increased stomach mucosa thickness ( J:84201 )

• antral mucosa is thickened, with disorganized, complex architecture

increased stomach tumor incidence ( J:84201 )

• stomach shows nodularity externally and polypoid, firm lesions intramucosally in a circumferential manner in the distal stomach

• mutants develop gastric tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
stomach cancer		DOID:10534	OMIM:613659	J:84201

Genotype
MGI:3028979

hm2

• Allelic Composition: Tff1^tm1Mrio/Tff1^tm1Mrio
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

neoplasm

increased adenoma incidence ( J:35923 )

• all homozygous mutant mice developed antropyloric adenomas

increased carcinoma incidence ( J:35923 )

• 30% of homozygous mutant mice developed multifocal intraepithelial or intramucosal carcinomas

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:35923 )

• enlarged villi, with infiltration of lymphoid cells

abnormal small intestine morphology ( J:35923 )

abnormal stomach morphology ( J:35923 )

increased stomach mucosa thickness ( J:35923 )

• antral and pyloric mucosa thicker; fundus mucosa was not