Phenotypes associated with this allele

• Allele Symbol: Poll^tm1Crey
• Allele Name: targeted mutation 1, Claude-Agnes Reynaud
• Allele ID: MGI:2179232
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Poll^tm1Crey/Poll^tm1Crey	involves: 129P2/OlaHsd	MGI:3851023
hm2	Poll^tm1Crey/Poll^tm1Crey	involves: 129P2/OlaHsd * C57BL/6	MGI:3851022
cx3	Poll^tm1Crey/Poll^tm1Crey Polm^tm1Crey/Polm^tm1Crey	involves: 129P2/OlaHsd	MGI:3851093

Genotype
MGI:3851023

hm1

• Allelic Composition: Poll^tm1Crey/Poll^tm1Crey
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal base-excision repair ( J:99087 )

• mouse embryonic fibroblasts exhibit impaired back-up base excision repair activity compared to in wild-type cells

homeostasis/metabolism

abnormal base-excision repair ( J:99087 )

• mouse embryonic fibroblasts exhibit impaired back-up base excision repair activity compared to in wild-type cells

immune system

immune system phenotype ( J:113406 )

N • light chain rearrangement is normal

abnormal immunoglobulin heavy chain V(D)J recombination ( J:113406 )

hematopoietic system

abnormal immunoglobulin heavy chain V(D)J recombination ( J:113406 )

Genotype
MGI:3851022

hm2

• Allelic Composition: Poll^tm1Crey/Poll^tm1Crey
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

reproductive system

reproductive system phenotype ( J:75927 )

N • despite expression in the testes, mice exhibit normal fertility

immune system

immune system phenotype ( J:75927 )

N • mice exhibit normal hypermutation patterns and B cell numbers

Genotype
MGI:3851093

cx3

• Allelic Composition: Poll^tm1Crey/Poll^tm1Crey; Polm^tm1Crey/Polm^tm1Crey
• Genetic Background: involves: 129P2/OlaHsd

immune system

abnormal B cell differentiation ( J:113406 )

• the transition from IgM- to IgM+ is impaired

abnormal immunoglobulin heavy chain V(D)J recombination ( J:113406 )

abnormal immunoglobulin light chain V-J recombination ( J:113406 )

decreased B cell number ( J:113406 )

hematopoietic system

abnormal B cell differentiation ( J:113406 )

• the transition from IgM- to IgM+ is impaired

abnormal immunoglobulin heavy chain V(D)J recombination ( J:113406 )

abnormal immunoglobulin light chain V-J recombination ( J:113406 )

decreased B cell number ( J:113406 )