Phenotypes associated with this allele

• Allele Symbol: Polm^tm1Crey
• Allele Name: targeted mutation 1, Claude-Agnes Reynaud
• Allele ID: MGI:2179233
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polm^tm1Crey/Polm^tm1Crey	involves: 129P2/OlaHsd	MGI:3851095
hm2	Polm^tm1Crey/Polm^tm1Crey	involves: 129P2/OlaHsd * C57BL/6	MGI:3040763
cx3	Poll^tm1Crey/Poll^tm1Crey Polm^tm1Crey/Polm^tm1Crey	involves: 129P2/OlaHsd	MGI:3851093
cx4	Dntt^tm1Gfn/Dntt^tm1Gfn Polm^tm1Crey/Polm^tm1Crey	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3851094

Genotype
MGI:3851095

hm1

• Allelic Composition: Polm^tm1Crey/Polm^tm1Crey
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal immunoglobulin light chain V-J recombination ( J:113406 )

immune system

abnormal immunoglobulin light chain V-J recombination ( J:113406 )

Genotype
MGI:3040763

hm2

• Allelic Composition: Polm^tm1Crey/Polm^tm1Crey
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

immune system phenotype ( J:75927 )

N • mice exhibit normal hypermutation patterns

abnormal B cell proliferation ( J:85190 )

• maturation of B cells from IgM- to IgM+ is slowed down

• light chain rearrangements are impaired

decreased B cell number ( J:75927 , J:85190 )

• in half of mice (J:75927)

• marked B cell deficiency in the spleen and Peyer's patches in about 50% of homozygotes (J:85190)

abnormal Peyer's patch morphology ( J:85190 )

• the separation of T and B cells into separate compartments is absent in Peyer's patches

• underdeveloped B cell compartment in Peyer's patches

lymphoid hypoplasia ( J:85190 )

• lower cellularity of peripheral lymphoid tissues (spleen and lymph nodes including Peyer's patches)

reproductive system

reproductive system phenotype ( J:75927 )

N • mice exhibit normal fertility

hematopoietic system

abnormal B cell proliferation ( J:85190 )

• maturation of B cells from IgM- to IgM+ is slowed down

• light chain rearrangements are impaired

decreased B cell number ( J:75927 , J:85190 )

• in half of mice (J:75927)

• marked B cell deficiency in the spleen and Peyer's patches in about 50% of homozygotes (J:85190)

cellular

abnormal B cell proliferation ( J:85190 )

• maturation of B cells from IgM- to IgM+ is slowed down

• light chain rearrangements are impaired

Genotype
MGI:3851093

cx3

• Allelic Composition: Poll^tm1Crey/Poll^tm1Crey; Polm^tm1Crey/Polm^tm1Crey
• Genetic Background: involves: 129P2/OlaHsd

immune system

abnormal B cell differentiation ( J:113406 )

• the transition from IgM- to IgM+ is impaired

abnormal immunoglobulin heavy chain V(D)J recombination ( J:113406 )

abnormal immunoglobulin light chain V-J recombination ( J:113406 )

decreased B cell number ( J:113406 )

hematopoietic system

abnormal B cell differentiation ( J:113406 )

• the transition from IgM- to IgM+ is impaired

abnormal immunoglobulin heavy chain V(D)J recombination ( J:113406 )

abnormal immunoglobulin light chain V-J recombination ( J:113406 )

decreased B cell number ( J:113406 )

Genotype
MGI:3851094

cx4

• Allelic Composition: Dntt^tm1Gfn/Dntt^tm1Gfn; Polm^tm1Crey/Polm^tm1Crey
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

hematopoietic system

abnormal immunoglobulin light chain V-J recombination ( J:113406 )

immune system

immune system phenotype ( J:113406 )

N • heavy chain rearrangement is normal

abnormal immunoglobulin light chain V-J recombination ( J:113406 )