All Phenotypes Gabra6<tm1Wwis> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gabra6^tm1Wwis
targeted mutation 1, W Wisden
MGI:2179278

Summary

2 genotypes

Allelic Composition	Gabra6^tm1Wwis/Gabra6^tm1Wwis
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra6^tm1Wwis mutation (0 available); any Gabra6 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:112951 )

N	• at 6 weeks of age, homozygotes show no signs of cochlear pathology, with normal hearing sensitivity, as determined by ABR/DPOAE assays across various test frequencies, and normal OHC efferent function, as assessed by measuring DPOAE suppression caused by efferent-bundle shocks

Allelic Composition	Gabra6^tm1Wwis/Gabra6^tm1Wwis
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra6^tm1Wwis mutation (0 available); any Gabra6 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:75896 )

N	• despite a selective (post-translational) loss of the delta subunit in cerebellar granule cells, homozygotes are grossly and behaviorally normal, with no significant differences in spontaneous and open field explorative activity or rotarod performance relative to wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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