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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfsf9tm1Thw
targeted mutation 1, Tania H Watts
MGI:2179297
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfsf9tm1Thw/Tnfsf9tm1Thw involves: 129 * C57BL/6 MGI:2655997
cx2
 		Cd28tm1Mak/Cd28tm1Mak
Tnfsf9tm1Thw/Tnfsf9tm1Thw 		involves: 129 * 129S2/SvPas * C57BL/6 MGI:2655998


Genotype
MGI:2655997
hm1
Allelic
Composition		 Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf9tm1Thw mutation (0 available); any Tnfsf9 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:76373 )
N
• mutants exhibit normal neutralizing IgM and IgG responses to vesicular stomatitis virus, unimpaired cytotoxic T cell responses to lymphocytic choriomeningitis virus, and normal skin allograft rejection
abnormal cytotoxic T cell physiology ( J:76373 )
• mutants exhibit weaker cytotoxic T cell responses to influenza virus

hematopoietic system
abnormal cytotoxic T cell physiology ( J:76373 )
• mutants exhibit weaker cytotoxic T cell responses to influenza virus




Genotype
MGI:2655998
cx2
Allelic
Composition		 Cd28tm1Mak/Cd28tm1Mak
Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic
Background		 involves: 129 * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Mak mutation (12 available); any Cd28 mutation (52 available)
Tnfsf9tm1Thw mutation (0 available); any Tnfsf9 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytotoxic T cell physiology ( J:76373 )
• mutants exhibit weaker cytotoxic T cell responses to influenza virus, but have unimpaired responses to lymphocytic chriomeningitis virus
increased length of allograft survival ( J:76373 )
• mutants exhibit a delay in skin allograft rejection of up to 14 days

hematopoietic system
abnormal cytotoxic T cell physiology ( J:76373 )
• mutants exhibit weaker cytotoxic T cell responses to influenza virus, but have unimpaired responses to lymphocytic chriomeningitis virus




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory