All Phenotypes Olig1<tm1(cre)Rth> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Olig1^tm1(cre)Rth
targeted mutation 1, David H Rowitch
MGI:2179311

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Olig1^tm1(cre)Rth/Olig1^tm1(cre)Rth	involves: 129S4/SvJae	MGI:5698610
hm2	Olig1^tm1(cre)Rth/Olig1^tm1(cre)Rth	involves: 129S4/SvJae * C57BL/6J	MGI:3620049
cn3	Ezh2^tm2Sho/Ezh2^tm2Sho Olig1^tm1(cre)Rth/0	involves: 129S1/Sv * 129S4/SvJae	MGI:6158438
cn4	Ncstn^tm1.1Sud/Ncstn^tm1.1Sud Olig1^tm1(cre)Rth/Olig1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:5800496
cn5	Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Olig1^tm1(cre)Rth/Olig1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:3620048
cn6	Chd7^tm1.1Dmm/Chd7^tm1.1Dmm Olig1^tm1(cre)Rth/Olig1⁺	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:6117077
cn7	Seh1l^tm1Lzha/Seh1l^tm1Lzha Olig1^tm1(cre)Rth/Olig1⁺	involves: 129S4/SvJae * C57BL/6	MGI:6712828
cn8	Olig1^tm1(cre)Rth/Olig1⁺ Secisbp2l^tm1.1Qiu/Secisbp2l^tm1.1Qiu	involves: 129S4/SvJaeSor * C57BL/6	MGI:7734972
cn9	Olig1^tm1(cre)Rth/Olig1^tm1(cre)Rth Dlx1^tm1Rth/Dlx1^tm1Rth Dlx2^tm1.1Rth/Dlx2^tm1.1Rth	involves: 129S/SvEv * 129S4/SvJae * C57BL/6	MGI:5698611
cn10	Olig1^tm1(cre)Rth/Olig1^tm1(cre)Rth Dlx1^tm1Rth/Dlx1⁺ Dlx2^tm1.1Rth/Dlx2⁺	involves: 129S/SvEv * 129S4/SvJae * C57BL/6	MGI:5698612

Allelic Composition	Olig1^tm1(cre)Rth/Olig1^tm1(cre)Rth
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:212992 )

N	• cortical volume like controls • no significant increase in inhibitory activity on pyramidal cells

abnormal brain interneuron morphology ( J:212992 )

• 35% increase in interneuron precursor cells expressing parvalbumin and calretinin but not neuropeptide-Y or somatostatin

• 30% increase in cells expressing GABA and GAD67

abnormal cerebral cortex pyramidal cell morphology ( J:212992 )

• increase in parvalbumin interneuron synapse on cortical pyramidal neurons

abnormal olfactory bulb interneuron morphology ( J:212992 )

• increased interneuron production in the olfactory bulb

abnormal cerebellum morphology ( J:212992 )

• increased interneuron production

decreased oligodendrocyte number ( J:212992 )

• in the corpus callosum, motor cortex, and cerebellar white matter at 21 and 50 days of age

• also reduced in the ventral telencephalon where there is a 30% increase of interneurons

Allelic Composition	Olig1^tm1(cre)Rth/Olig1^tm1(cre)Rth
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal oligodendrocyte morphology ( J:75868 )

• markers of oligodendrocyte progenitors in the white matter of the spinal cord are delayed, suggesting that maturation of oligodendrocytes in mutants is affected

Allelic Composition	Ezh2^tm2Sho/Ezh2^tm2Sho Olig1^tm1(cre)Rth/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2^tm2Sho mutation (1 available); any Ezh2 mutation (72 available)
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal oligodendrocyte morphology ( J:256017 )

• lower percentage of CC1+ differentiating oligodendrocytes amongst Olig2+ oligodendrocytes in brain at age P7

• lower number of Mbp+ mature oligodendrocytes in brain at age P7

dysmyelination ( J:256017 )

• reduced myelination of axons in optic nerves at age P15

• thinner myelin sheaths around axons in optic nerves at age P15

Allelic Composition	Ncstn^tm1.1Sud/Ncstn^tm1.1Sud Olig1^tm1(cre)Rth/Olig1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncstn^tm1.1Sud mutation (0 available); any Ncstn mutation (34 available)
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased exploration in new environment ( J:234705 )

• mice exhibit increased exploratory behavior in both the open field and elevated plus maze

increased grooming behavior ( J:234705 )

• compulsive grooming in symptomatic mice

• presymptomatic mice show a trend towards excessive grooming

hyperactivity ( J:234705 )

• mice are hyperactive in both the open field and elevated plus maze

• treatment with an acute intraperitoneal injection of a low dose of haloperidol reverses the hyperactivity but does not alter the thigmotaxis in the open field maze

increased stereotypic behavior ( J:234705 )

• mice exhibit trichotillomania

integument

abnormal coat appearance ( J:234705 )

• aged mice exhibit extensive bald patches localized to the nape of the neck and upper back

skin lesions ( J:234705 )

• bald patches progress to full lesions with 100% penetrance by 9 months of age

• lesions are self-inflicted and not caused by social grooming

• lesions are not responsive to topical antibiotic, anti-inflammatory, or antihistamine treatment and mice do not exhibit a difference in response to histamine injection compared to controls

nervous system

decreased myelin sheath thickness ( J:234705 )

• thinner myelin sheaths in the optic nerve, indicating hypomyelination in the optic nerve

• however, myelination in the spinal cord and sciatic nerve is normal

dysmyelination ( J:234705 )

• hypomyelination in the optic nerve

decreased prepulse inhibition ( J:234705 )

• mice are less sensitive to the prepulse and thus show reduced inhibition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:234705

Allelic Composition	Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Olig1^tm1(cre)Rth/Olig1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Mrc mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:105927 )

• double heterozygotes are viable to E18.0 but no live mice are recovered

nervous system

absent oligodendrocytes ( J:105927 )

• oligodendrocytes cannot be detected in mutant embryos examined from E12.5-18

decreased motor neuron number ( J:105927 )

• at E10.0, few motor neurons are detectable in the ventral spinal cord compared to wild-type; this result is consistent from E10.5-14

Allelic Composition	Chd7^tm1.1Dmm/Chd7^tm1.1Dmm Olig1^tm1(cre)Rth/Olig1⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7^tm1.1Dmm mutation (1 available); any Chd7 mutation (138 available)
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased oligodendrocyte number ( J:234565 )

• decrease in the number of MBP+ oligodendrocytes in the spinal cord

• decrease in the number of CC1+ oligodendrocytes and oligodendrocyte lineage cells in the cortices

• number of CC1+ oligodendrocytes increases with age, eventually reaching control levels in the spinal cord

decreased myelin sheath thickness ( J:234565 )

• at P28 in the optic nerve

dysmyelination ( J:234565 )

• decrease in the number of myelinated axons at P14 in the optic nerve

• degree of hypomyelination decreases with age with no difference detected in the spinal cord at P60

Allelic Composition	Seh1l^tm1Lzha/Seh1l^tm1Lzha Olig1^tm1(cre)Rth/Olig1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (14 available)
Seh1l^tm1Lzha mutation (0 available); any Seh1l mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:276253 )

• mice die during the third postnatal week

behavior/neurological

tremors ( J:276253 )

• mice develop tremors from postnatal week 2

ataxia ( J:276253 )

• mice develop ataxia from postnatal week 2

seizures ( J:276253 )

• mice develop seizures from postnatal week 2

nervous system

seizures ( J:276253 )

• mice develop seizures from postnatal week 2

abnormal brain development ( J:276253 )

• oligodendrocyte progenitor cells do not differentiate into MBP+, CNP+ oligodendrocytes after tri-iodothyronine induction, indicating oligodendrocyte progenitor cell differentiation defects

decreased oligodendrocyte number ( J:276253 )

• reduction of mature oligodendrocytes

• however, oligodendrocyte progenitor cell markers are detected in the spinal cord and brain at P4, P7, and P14 and oligodendrocyte progenitor cell proliferation rates are normal and markers of mature neurons, astrocytes, and microglia are similar to wild-type

dysmyelination ( J:276253 )

• optic nerve is translucent indicating a deficiency of myelin formation

• myelinated axons are hardly detectable in the optic nerve, corpus callosum, or spinal cord at P14

cellular

abnormal cell differentiation ( J:276253 )

• oligodendrocyte progenitor cells do not differentiate into MBP+, CNP+ oligodendrocytes after tri-iodothyronine induction, indicating oligodendrocyte progenitor cell differentiation defects

Allelic Composition	Olig1^tm1(cre)Rth/Olig1⁺ Secisbp2l^tm1.1Qiu/Secisbp2l^tm1.1Qiu
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (14 available)
Secisbp2l^tm1.1Qiu mutation (0 available); any Secisbp2l mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased oligodendrocyte number ( J:333465 )

• decrease in the number of Plp1+ mature oligodendrocytes from P0 to P15

decreased myelin sheath thickness ( J:333465 )

• in the white matter of the spinal cord at P15

abnormal oligodendrocyte differentiation ( J:333465 )

• decrease in the number of Plp1+ mature oligodendrocytes from P0 to P15

• treatment with a T3 analog (GC-1) but not with T4, stimulates oligodendrocyte differentiation

homeostasis/metabolism

increased thyroxine level ( J:333465 )

• increased T4 levels in brain and spinal cord lysates

decreased triiodothyronine level ( J:333465 )

• decreased T3 levels in brain and spinal cord lysates

behavior/neurological

tremors ( J:333465 )

• strong trembling in tail suspension assays at P15 and at P45

Allelic Composition	Olig1^tm1(cre)Rth/Olig1^tm1(cre)Rth Dlx1^tm1Rth/Dlx1^tm1Rth Dlx2^tm1.1Rth/Dlx2^tm1.1Rth
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx1^tm1Rth mutation (1 available); any Dlx1 mutation (21 available)
Dlx2^tm1.1Rth mutation (1 available); any Dlx2 mutation (25 available)
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:212992 )

• mice are always dead before 21 days of age

neonatal lethality, incomplete penetrance ( J:212992 )

• mice fail to thrive and tend to die in the neonatal period

Allelic Composition	Olig1^tm1(cre)Rth/Olig1^tm1(cre)Rth Dlx1^tm1Rth/Dlx1⁺ Dlx2^tm1.1Rth/Dlx2⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:212992 )

N	• mice survive to adulthood

nervous system

nervous system phenotype ( J:212992 )

N	• interneuron numbers tend to be more normal

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