Phenotypes associated with this allele

• Allele Symbol: Col1a1^tm1Bst
• Allele Name: targeted mutation 1, Paul Bornstein
• Allele ID: MGI:2179405
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Col1a1^tm1Bst/Col1a1^tm1Bst	involves: 129P2/OlaHsd * C57BL/6	MGI:3620101

Genotype
MGI:3620101

hm1

• Allelic Composition: Col1a1^tm1Bst/Col1a1^tm1Bst
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:92016 )

• spontaneous deaths start at 4 months of age, with 54% dead by 18 months of age

cardiovascular system

abnormal aorta tunica adventitia morphology ( J:92016 )

• reduction in fibrillar collagen in the adventitia

abnormal aorta elastic tissue morphology ( J:92016 )

• elastic lamellae in aortas are less compacted, more variable in width, display irregular boarders, and are surrounded by less dense collagen fibrils

aortic dissection ( J:92016 )

• susceptible to the development of age-dependent aortic dissection and rupture

aneurysm ( J:92016 )

• 15 of 17 exhibit an aneurysm

hemorrhage ( J:92016 )

• observe hematoma, which is associated with aortic dissection, surrounding the heart or pericardial sac and extending through the diaphragm into the peritoneal cavity