Phenotypes associated with this allele

• Allele Symbol: Dffa^tm1Mxu
• Allele Name: targeted mutation 1, Ming Xu
• Allele ID: MGI:2179456
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dffa^tm1Mxu/Dffa^tm1Mxu	involves: 129S4/SvJae * C57BL/6	MGI:3034051
cx2	Dffa^tm1Mxu/Dffa^tm1Mxu Endog/D2Wsu81e^tm1Mxu/Endog^+	involves: 129 * C57BL/6	MGI:3034049
cx3	Spout1^tm1Mxu/Spout1^+ Dffa^tm1Mxu/Dffa^tm1Mxu	involves: 129 * C57BL/6	MGI:3514288

Genotype
MGI:3034051

hm1

• Allelic Composition: Dffa^tm1Mxu/Dffa^tm1Mxu
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal apoptosis ( J:50707 , J:88144 )

• induction of apoptosis in bone marrow granulocytes by cyclohexamine is reduced (J:50707)

• DNA condensation in splenocytes and thymocytes is severely impaired (J:50707)

• reduced apoptosis of splenocytes and thymocytes after treatment with apoptotic stimuli (J:88144)

• DNA fragmentation was essentially eliminated in splenocytes and thymocytes after treatment with various apoptotic stimuli (J:88144)

decreased susceptibility to neuronal excitotoxicity ( J:114416 )

• less neuronal cell loss in CA3 as a result of kainic acid injection, fewer mice with lesions and smaller lesions

behavior/neurological

abnormal spatial learning ( J:76476 )

• improved performance in the hidden-platform version of the Morris water maze

• learning occurs more quickly

• better performance than controls in probe-trial tests

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:114416 )

• less neuronal cell loss in CA3 as a result of kainic acid injection, fewer mice with lesions and smaller lesions

abnormal dentate gyrus morphology ( J:76476 )

• higher mean granule cell density in the dentate region of the hippocampus whereas cell densities are normal in CA3 and CA1

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:114416 )

• less neuronal cell loss in CA3 as a result of kainic acid injection, fewer mice with lesions and smaller lesions

Genotype
MGI:3034049

cx2

• Allelic Composition: Dffa^tm1Mxu/Dffa^tm1Mxu; Endog/D2Wsu81e^tm1Mxu/Endog⁺
• Genetic Background: involves: 129 * C57BL/6

cellular

decreased apoptosis ( J:88144 )

• apoptosis and DNA fragmentation were essentially eliminated in splenocytes and thymocytes after treatment with apoptotic stimuli

Genotype
MGI:3514288

cx3

• Allelic Composition: Spout1^tm1Mxu/Spout1⁺; Dffa^tm1Mxu/Dffa^tm1Mxu
• Genetic Background: involves: 129 * C57BL/6

cellular

decreased apoptosis ( J:88144 )

• apoptosis and DNA fragmentation were essentially eliminated in splenocytes and thymocytes after treatment with apoptotic stimuli