All Phenotypes Daxx<tm1Led> MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:56796 )

• on a 129S6/SvEvTac genetic backrgound, homozygous mutant embryos are evident at E8.5, although in lower than expected ratios; no mutant embryos are obtained after E9.5

• on a 129S6/SvEvTac x Black Swiss outbred background, homozygous mutant mice are identified at E9.5, but not later

increased embryonic tissue cell apoptosis ( J:56796 )

• E7.5 homozygous mutant embryos display significantly increased levels of apoptosis (TUNEL assay)

• at E8.5, high levels of apoptosis are particularly striking in the allantois as well as in the head and tail regions of the neuroepithelium; apoptosis is also noted in the population of fetal hematopoietic cells

• a similar apoptosis phenotype is observed in homozygous mutant cell lines, established by culturing the inner cell mass of blastocysts derived from matings of heterozygous 129/SvEv mice

increased allantois apoptosis ( J:56796 )

• at E8.5, high levels of apoptosis are particularly striking in the allantois

increased embryonic neuroepithelium apoptosis ( J:56796 )

• at E8.5, high levels of apoptosis are particularly striking in the head and tail regions of the neuroepithelium

embryo phenotype ( J:56796 )

N	• at E8.5, extraembryonic structures such as the yolk sac and amnion are apparent, and some primitive fetal blood formation is noted in homozygous mutant embryos

increased embryonic tissue cell apoptosis ( J:56796 )

• E7.5 homozygous mutant embryos display significantly increased levels of apoptosis (TUNEL assay)

• at E8.5, high levels of apoptosis are particularly striking in the allantois as well as in the head and tail regions of the neuroepithelium; apoptosis is also noted in the population of fetal hematopoietic cells

• a similar apoptosis phenotype is observed in homozygous mutant cell lines, established by culturing the inner cell mass of blastocysts derived from matings of heterozygous 129/SvEv mice

increased allantois apoptosis ( J:56796 )

• at E8.5, high levels of apoptosis are particularly striking in the allantois

abnormal ectoderm development ( J:56796 )

• in E7.5 homozygous mutant embryos, ectoderm-derived cells fail to organize as a uniform layer but, rather, remain as a clump of cells

decreased embryo size ( J:56796 )

• at E7.5, homozygous mutant embryos are significantly smaller than wild-type embryos

• by E8.5 and E9.5, the decreased embryo size is highly pronounced

abnormal embryonic tissue morphology ( J:56796 )

• at E7.5, H & E staining revealed that homozygous mutant embryos are highly disorganized compared to wild-type embryos

• by E8.5 and E9.5, the extensive disorganization of homozygous mutant embryos is highly pronounced

absent somites ( J:56796 )

• at E8.5, homozygous mutant embryos lack somite formation and fail to develop specific tissue types or organs

absent placenta ( J:56796 )

• at E8.5, the placenta is absent in homozygous mutant embryos

decreased embryo size ( J:56796 )

• at E7.5, homozygous mutant embryos are significantly smaller than wild-type embryos

• by E8.5 and E9.5, the decreased embryo size is highly pronounced

increased embryonic neuroepithelium apoptosis ( J:56796 )

• at E8.5, high levels of apoptosis are particularly striking in the head and tail regions of the neuroepithelium

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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