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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slit1tm1.1Matl
targeted mutation 1.1, Marc Tessier-Lavigne
MGI:2179459
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slit1tm1.1Matl/Slit1tm1.1Matl involves: 129S2/SvPas MGI:3772918
cx2
 		Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl
Slit3tm1.1Dor/Slit3+ 		involves: 129S1/Sv * 129S2/SvPas MGI:3043191
cx3
 		Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl
Slit3tm1.1Dor/Slit3tm1.1Dor 		involves: 129S1/Sv * 129S2/SvPas MGI:3043188
cx4
 		Slit1tm1.1Matl/Slit1+
Slit2tm1Matl/Slit2tm1Matl 		involves: 129S2/SvPas MGI:5522762
cx5
 		Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl 		involves: 129S2/SvPas MGI:3772917
cx6
 		Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2+ 		involves: 129S2/SvPas MGI:5522757
cx7
 		Robo3tm1Matl/Robo3tm1Matl
Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl 		involves: 129/Sv * CD-1 MGI:3043203
cx8
 		Robo3tm1Matl/Robo3tm1Matl
Slit1tm1.1Matl/Slit1tm1.1Matl 		involves: 129/Sv * CD-1 MGI:3043196


Genotype
MGI:3772918
hm1
Allelic
Composition		 Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation (0 available); any Slit1 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:130430 )
N
• mice exhibit normal morphology and numbers of interneurons during development




Genotype
MGI:3043191
cx2
Allelic
Composition		 Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl
Slit3tm1.1Dor/Slit3+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation (0 available); any Slit1 mutation (71 available)
Slit2tm1Matl mutation (2 available); any Slit2 mutation (88 available)
Slit3tm1.1Dor mutation (1 available); any Slit3 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon guidance ( J:89780 )
• at E12.5 commissural axons occasionally recross the floor plate, this is never seen in controls
abnormal spinal cord ventral commissure morphology ( J:89780 )
• the ventral commissure (bundle of nerve fibers passing from one side to the other in the spinal cord) appears thicker compared to controls
abnormal spinal cord lateral column morphology ( J:89780 )
• the ventral funiculus (white matter tract) appears reduced in mutants compared to controls

cellular
abnormal axon guidance ( J:89780 )
• at E12.5 commissural axons occasionally recross the floor plate, this is never seen in controls




Genotype
MGI:3043188
cx3
Allelic
Composition		 Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl
Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation (0 available); any Slit1 mutation (71 available)
Slit2tm1Matl mutation (2 available); any Slit2 mutation (88 available)
Slit3tm1.1Dor mutation (1 available); any Slit3 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon guidance ( J:89780 )
• at E12.5 commissural axons appear disorganized as they exit the floor plate lacking the typical bundled morphology
• at E12.5 more commissural axons stall and fail to exit the floor plate (78% versus 28% in controls) or recross the floor plate (~20% versus 0% in controls; controls in this study were Slit1tm1.1Matl homozygotes)
abnormal spinal cord lateral column morphology ( J:89780 )
• the lateral funiculus (white matter tract) is significantly thinner in triple homozygous mutants compared to controls

cellular
abnormal axon guidance ( J:89780 )
• at E12.5 commissural axons appear disorganized as they exit the floor plate lacking the typical bundled morphology
• at E12.5 more commissural axons stall and fail to exit the floor plate (78% versus 28% in controls) or recross the floor plate (~20% versus 0% in controls; controls in this study were Slit1tm1.1Matl homozygotes)




Genotype
MGI:5522762
cx4
Allelic
Composition		 Slit1tm1.1Matl/Slit1+
Slit2tm1Matl/Slit2tm1Matl
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation (0 available); any Slit1 mutation (71 available)
Slit2tm1Matl mutation (2 available); any Slit2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory tract morphology ( J:119469 )
• some small bundles diverge from the main tract and extend ventrally, at E18.5




Genotype
MGI:3772917
cx5
Allelic
Composition		 Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation (0 available); any Slit1 mutation (71 available)
Slit2tm1Matl mutation (2 available); any Slit2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
nervous system phenotype ( J:130430 )
N
• mice exhibit normal numbers of interneurons during development
abnormal olfactory lobe morphology ( J:119469 )
• density of LOT (guidepost) cells is slightly decreased rostrally near the ventral part of the olfactory bulb
abnormal olfactory tract morphology ( J:119469 )
• highly defasciculated into small axonal bundles fanned all over the ventral side of the telencephalon although a subset of axons continue on the normal trajectory, at E18.5
• medial axons are more severely affected than lateral axons
abnormal embryonic/fetal subventricular zone morphology ( J:130430 )
• at E13.5 and E16.5, cell proliferation of ganglionic eminences in the subventricular zone is increased compared to in Slit1tm1.1Matl homozygotes
abnormal neurite morphology ( J:130430 )
• in the subventricular zone/intermediate zone and subplate, mic exhibit an increased in neurite process length is, the number of neurites, and the degree of branching




Genotype
MGI:5522757
cx6
Allelic
Composition		 Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation (0 available); any Slit1 mutation (71 available)
Slit2tm1Matl mutation (2 available); any Slit2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory tract morphology ( J:119469 )
• thinner and beginning to divide into bundles at E14.5




Genotype
MGI:3043203
cx7
Allelic
Composition		 Robo3tm1Matl/Robo3tm1Matl
Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl
Genetic
Background		 involves: 129/Sv * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo3tm1Matl mutation (1 available); any Robo3 mutation (76 available)
Slit1tm1.1Matl mutation (0 available); any Slit1 mutation (71 available)
Slit2tm1Matl mutation (2 available); any Slit2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon guidance ( J:89438 )
• embryos show some midline crossing although the majority still fail to cross indicating a partial rescue of the Robo3tm1Matl homozygous phenotype

cellular
abnormal axon guidance ( J:89438 )
• embryos show some midline crossing although the majority still fail to cross indicating a partial rescue of the Robo3tm1Matl homozygous phenotype




Genotype
MGI:3043196
cx8
Allelic
Composition		 Robo3tm1Matl/Robo3tm1Matl
Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic
Background		 involves: 129/Sv * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo3tm1Matl mutation (1 available); any Robo3 mutation (76 available)
Slit1tm1.1Matl mutation (0 available); any Slit1 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon guidance ( J:89438 )
• embryos show no midline crossing and look identical to Robo3tm1Matl homozygous littermates

cellular
abnormal axon guidance ( J:89438 )
• embryos show no midline crossing and look identical to Robo3tm1Matl homozygous littermates




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory