Phenotypes associated with this allele

• Allele Symbol: Mycn^tm1Knd
• Allele Name: targeted mutation 1, Hisato Kondoh
• Allele ID: MGI:2179462
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mycn^tm1Knd/Mycn^tm1Knd	involves: 129P2/OlaHsd * BALB/c	MGI:2180133

Genotype
MGI:2180133

hm1

• Allelic Composition: Mycn^tm1Knd/Mycn^tm1Knd
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:11859 , J:76279 )

• embryos die between E11-E12 (J:11859)

cardiovascular system

thin myocardium ( J:11859 )

common ventricle ( J:11859 )

• absence of interventricular septum

small heart ( J:11859 )

trabecula carnea hypoplasia ( J:11859 )

digestive/alimentary system

abnormal stomach morphology ( J:11859 )

• absence of bulging stomach structure at E11

limbs/digits/tail

abnormal limb development ( J:11859 )

• failure of distal limb structure formation in explant cultures and in embryos

abnormal limb bud morphology ( J:11859 )

• at E11.5, limb buds do not show a gain in width and the limb plates are formed poorly or not at all

abnormal apical ectodermal ridge morphology ( J:11859 )

• at E11.5, apical ridges are formed but display a slightly rounder external contour than normal

liver/biliary system

abnormal liver development ( J:11859 )

• smaller than normal and existing as a single lobe instead of four major lobes

small liver ( J:11859 )

respiratory system

impaired branching involved in bronchus morphogenesis ( J:11859 )

• lungs in explant culture do not develop bronchial branches and remain Y-shaped

• branching defect is largely corrected by addition of fetal calf serum to the culture medium

nervous system

nervous system phenotype ( J:11859 )

N • normal autonomic nervous system innervation

abnormal neural tube morphology ( J:11859 )

• thin tubes; 20% less cells and 2/3 average wall section thickness

abnormal brain morphology ( J:11859 )

• slightly less expansion of the brain

small dorsal root ganglion ( J:11859 )

• spinal ganglia are generally thinner and smaller than normal

• rostral ganglia are more severely affected

embryo

abnormal limb bud morphology ( J:11859 )

• at E11.5, limb buds do not show a gain in width and the limb plates are formed poorly or not at all

abnormal apical ectodermal ridge morphology ( J:11859 )

• at E11.5, apical ridges are formed but display a slightly rounder external contour than normal

abnormal neural tube morphology ( J:11859 )

• thin tubes; 20% less cells and 2/3 average wall section thickness

muscle

trabecula carnea hypoplasia ( J:11859 )

thin myocardium ( J:11859 )

growth/size/body

decreased body length ( J:11859 )

• at E11.5, the trunk is appreciably smaller than normal