Phenotypes associated with this allele

• Allele Symbol: Or10a4^tm1Mom
• Allele Name: targeted mutation 1, Peter Mombaerts
• Allele ID: MGI:2179510
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Or10a4^tm1Mom/Or10a4^tm1Mom	involves: 129P2/OlaHsd * C57BL/6	MGI:3694215
ht2	Or10a4^tm1Mom/Or10a4^tm7Mom	involves: 129P2/OlaHsd * C57BL/6	MGI:3694214
cx3	Or10a4^tm1Mom/Or10a4^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-APPSwInd)Dbo/0	involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J	MGI:5811881
cx4	Ebf2^tm3.1(Zfp423*)Reed/Ebf2^+ Or10a4^tm1Mom/Or10a4^+	involves: 129 * 129P2/OlaHsd * C57BL/10J	MGI:5461572
cx5	Or10a4^tm1Mom/Or10a4^+ Ttc8^tm1Reed/Ttc8^tm1Reed	involves: 129 * 129P2/OlaHsd * C57BL/6	MGI:5140728
cx6	Adcy3^tm1Drs/Adcy3^tm1Drs Or10a4^tm1Mom/Or10a4^+	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3714865

Genotype
MGI:3694215

hm1

• Allelic Composition: Or10a4^tm1Mom/Or10a4^tm1Mom
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olfactory neuron innervation pattern ( J:90716 )

• axons coalesce into separate glomeruli

Genotype
MGI:3694214

ht2

• Allelic Composition: Or10a4^tm1Mom/Or10a4^tm7Mom
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

abnormal olfactory neuron innervation pattern ( J:90716 )

• partial segregation of P2*-LacZ and P2-GFP axons within glomeruli occurs

• axons co-converge but do not co-mingle

Genotype
MGI:5811881

cx3

• Allelic Composition: Or10a4^tm1Mom/Or10a4⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-APPSwInd)Dbo/0
• Genetic Background: involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J

craniofacial

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

growth/size/body

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

nervous system

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

abnormal olfactory bulb layer morphology ( J:199798 )

• no obvious Olfr17+ axonal convergence is seen in the olfactory bulb

respiratory system

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

taste/olfaction

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

Genotype
MGI:5461572

cx4

• Allelic Composition: Ebf2^{tm3.1(Zfp423*)Reed}/Ebf2⁺; Or10a4^tm1Mom/Or10a4⁺
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

nervous system

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of labeled sensory neurons in the olfactory bulb

craniofacial

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of labeled sensory neurons in the olfactory bulb

respiratory system

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of labeled sensory neurons in the olfactory bulb

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of labeled sensory neurons in the olfactory bulb

growth/size/body

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of labeled sensory neurons in the olfactory bulb

Genotype
MGI:5140728

cx5

• Allelic Composition: Or10a4^tm1Mom/Or10a4⁺; Ttc8^tm1Reed/Ttc8^tm1Reed
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Impaired glomerular formation in Ttc8^tm1Reed/Ttc8^tm1Reed Or10a4^tm1Mom/Or10a4⁺ neonatal pups

nervous system

abnormal axon guidance ( J:173465 )

• abnormal targeting of labeled olfactory sensory neuron axons is observed at P0

cellular

abnormal axon guidance ( J:173465 )

• abnormal targeting of labeled olfactory sensory neuron axons is observed at P0

Genotype
MGI:3714865

cx6

• Allelic Composition: Adcy3^tm1Drs/Adcy3^tm1Drs; Or10a4^tm1Mom/Or10a4⁺
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

nervous system

abnormal olfactory nerve morphology ( J:122528 )

• Olfr17+ neurons fail to innervate glomeruli

• fewer Olfr17+ neurons are present (118+/-6 compared to 486+/-46 in wild-type mice)