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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad2tm1Rak
targeted mutation 1, Raju Kucherlapati
MGI:2179521
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smad2tm1Rak/Smad2tm1Rak involves: 129/Sv * C57BL/6J * SJL MGI:3796823


Genotype
MGI:3796823
hm1
Allelic
Composition		 Smad2tm1Rak/Smad2tm1Rak
Genetic
Background		 involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm1Rak mutation (0 available); any Smad2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:73507 )
• embryos die around day 7.5 of gestation due to abnormal embryonic ectoderm development

embryo
abnormal embryonic tissue morphology ( J:73507 )
• analysis of day 8.5 conceptuses shows absence of embryonic ectoderm derivatives, but apparently normal yolk-sac membrane and tissues of mesoderm origin
• well-organized columnar embryonic ectoderm epithelium is indistinguishable in day 7.0 embryos




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory