Phenotypes associated with this allele

• Allele Symbol: Fgf18^tm1Sjt
• Allele Name: targeted mutation 1, Shinji Takada
• Allele ID: MGI:2179607
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf18^tm1Sjt/Fgf18^tm1Sjt	B6.129S1-Fgf18^tm1Sjt	MGI:4430498
hm2	Fgf18^tm1Sjt/Fgf18^tm1Sjt	involves: 129S1/Sv * C57BL/6	MGI:2667630
cx3	Fgf18^tm1Sjt/Fgf18^+ Glg1^Gt(KST005)Byg/Glg1^+	B6.129-Glg1^Gt(KST005)Byg Fgf18^tm1Sjt	MGI:4430496
cx4	Fgf18^tm1Sjt/Fgf18^tm1Sjt Glg1^Gt(KST005)Byg/Glg1^Gt(KST005)Byg	B6.129-Glg1^Gt(KST005)Byg Fgf18^tm1Sjt	MGI:4430497
cx5	Fgf18^tm1Sjt/Fgf18^+ Glg1^Gt(KST005)Byg/Glg1^Gt(KST005)Byg	B6.129-Glg1^Gt(KST005)Byg Fgf18^tm1Sjt	MGI:4430499
cx6	Fgf18^tm1Sjt/Fgf18^tm1Sjt Glg1^Gt(KST005)Byg/Glg1^+	B6.129-Glg1^Gt(KST005)Byg Fgf18^tm1Sjt	MGI:4430501

Genotype
MGI:4430498

hm1

• Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt
• Genetic Background: B6.129S1-Fgf18^tm1Sjt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:157157 )

• mice die at birth

skeleton

abnormal rib morphology ( J:157157 )

• the ribs are slightly distorted

Genotype
MGI:2667630

hm2

• Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt
• Genetic Background: involves: 129S1/Sv * C57BL/6

mortality/aging

perinatal lethality, complete penetrance ( J:75880 )

• mice die just prior to or at birth

limbs/digits/tail

short radius ( J:75880 )

• decreased length

short ulna ( J:75880 )

• decreased length

abnormal fibula morphology ( J:75880 )

• incomplete ossification

short tibia ( J:75880 )

skeleton

short radius ( J:75880 )

• decreased length

short ulna ( J:75880 )

• decreased length

abnormal fibula morphology ( J:75880 )

• incomplete ossification

short tibia ( J:75880 )

abnormal rib morphology ( J:75880 )

• resulting in reduction of the volume of the thoracic cavity

kyphosis ( J:75880 )

• observed in the cervical and upper thoracic spine at E18.5

delayed bone ossification ( J:75880 )

• unossified areas of the calvaria were larger than those of wild-type

• decreased proliferation of calvarial osteogenic mesenchymal cells

• delay of terminal differentiation of the calvarial osteoblasts

• delay of osteogenic differentiation also observed

delayed cranial suture closure ( J:75880 )

• suture closure is delayed

growth/size/body

small thoracic cavity ( J:75880 )

respiratory system

abnormal lung vasculature morphology ( J:91986 )

• many embedded capillaries seen at E18.5, unlike in wild-type lungs where capillaries closely abutting alveolar spaces are observed

abnormal lung development ( J:91986 )

• impaired remodeling of the distal lung during the terminal saccular stage

• transient reduction in lung cell proliferation during the terminal saccular stage

• normal proximal and distal airway branching

• normal differentiation of lung epithelial cells at E18.5

abnormal lung saccule morphology ( J:91986 )

• significantly reduced alveolar spaces at E18.5

thick lung-associated mesenchyme ( J:91986 )

• thicker interstitial mesenchymal compartments at E18.5

small lung lobe ( J:91986 )

• all lung lobes are a little smaller than normal at E18.5

• however, number and orientation of lobes is normal

small lung ( J:91986 )

• slightly smaller lungs at E18.5

cardiovascular system

abnormal lung vasculature morphology ( J:91986 )

• many embedded capillaries seen at E18.5, unlike in wild-type lungs where capillaries closely abutting alveolar spaces are observed

Genotype
MGI:4430496

cx3

• Allelic Composition: Fgf18^tm1Sjt/Fgf18⁺; Glg1^{Gt(KST005)Byg}/Glg1⁺
• Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt

growth/size/body

decreased body weight ( J:157157 )

• males are smaller at 1 month and females are smaller by 3 months

limbs/digits/tail

abnormal tail morphology ( J:157157 )

• males are smaller at 1 month and females are smaller by 3 months

Genotype
MGI:4430497

cx4

• Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt; Glg1^{Gt(KST005)Byg}/Glg1^{Gt(KST005)Byg}
• Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt

mortality/aging

neonatal lethality, complete penetrance ( J:157157 )

• mice die at birth

limbs/digits/tail

abnormal tail morphology ( J:157157 )

• tails of neonates are distorted

skeleton

abnormal rib morphology ( J:157157 )

• mice die at birth

abnormal spine curvature ( J:157157 )

• more severe curvature of the spine than Fgf18 null alone

Genotype
MGI:4430499

cx5

• Allelic Composition: Fgf18^tm1Sjt/Fgf18⁺; Glg1^{Gt(KST005)Byg}/Glg1^{Gt(KST005)Byg}
• Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt

mortality/aging

postnatal lethality, incomplete penetrance ( J:157157 )

• mortality is similar to Glg1 single mutants

limbs/digits/tail

abnormal tail morphology ( J:157157 )

• tails of neonates are distorted

skeleton

abnormal skeleton morphology ( J:157157 )

• skeletal deformities are similar to those in Glg1 single mutants

Genotype
MGI:4430501

cx6

• Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt; Glg1^{Gt(KST005)Byg}/Glg1⁺
• Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt

mortality/aging

neonatal lethality, complete penetrance ( J:157157 )

• mice die at birth

skeleton

abnormal rib morphology ( J:157157 )

• mice die at birth

abnormal spine curvature ( J:157157 )