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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccr6tm1Gma
targeted mutation 1, Gabriel Marquez
MGI:2179613
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccr6tm1Gma/Ccr6tm1Gma involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3621959
cx2
 		Ccr6tm1Gma/Ccr6tm1Gma
Tg(Rorc-EGFP)1Ebe/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3829420


Genotype
MGI:3621959
hm1
Allelic
Composition		 Ccr6tm1Gma/Ccr6tm1Gma
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1Gma mutation (3 available); any Ccr6 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased leukocyte cell number ( J:68191 )
• mice have a decreased number of leukocytes in Peyer's patches compared to wild-type
increased leukocyte cell number ( J:68191 )
• there is a 2 fold increase in total lymphocytes in the intraepithelial lymphocyte subpopulation
abnormal myeloid dendritic cell morphology ( J:68191 )
• subpopulations of myeloid dendritic cells are aberrantly positioned compared to wild-type
abnormal CD4-positive, alpha-beta T cell physiology ( J:68191 )
• host mice are unable to develop an inflammatory response when injected with CD4+ T cells from null animals
abnormal Peyer's patch morphology ( J:68191 )
• mice have underdeveloped Peyer's patches compared to wild-type
abnormal Peyer's patch follicle morphology ( J:68191 )
• Peyer's patches from mutants show a lower number of developed follicles than wild-type animals
decreased inflammatory response ( J:68191 )
• sensitized null mice show less inflammation to subsequent injection of allogeneic splenocytes

hematopoietic system
decreased leukocyte cell number ( J:68191 )
• mice have a decreased number of leukocytes in Peyer's patches compared to wild-type
increased leukocyte cell number ( J:68191 )
• there is a 2 fold increase in total lymphocytes in the intraepithelial lymphocyte subpopulation
abnormal myeloid dendritic cell morphology ( J:68191 )
• subpopulations of myeloid dendritic cells are aberrantly positioned compared to wild-type
abnormal CD4-positive, alpha-beta T cell physiology ( J:68191 )
• host mice are unable to develop an inflammatory response when injected with CD4+ T cells from null animals




Genotype
MGI:3829420
cx2
Allelic
Composition		 Ccr6tm1Gma/Ccr6tm1Gma
Tg(Rorc-EGFP)1Ebe/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1Gma mutation (3 available); any Ccr6 mutation (37 available)
Tg(Rorc-EGFP)1Ebe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are significantly increased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly increased

hematopoietic system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are significantly increased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly increased




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory