All Phenotypes Nfkb2<tm1Brv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfkb2^tm1Brv/Nfkb2^tm1Brv	involves: 129S1/Sv * C57BL/6	MGI:3852509
ht2	Nfkb2^tm1Brv/Nfkb2⁺	involves: 129S1/Sv * C57BL/6	MGI:3852510
cx3	Nfkb1^tm1Brv/Nfkb1^tm1Brv Nfkb2^tm1Brv/Nfkb2^tm1Brv	involves: 129S1/Sv * C57BL/6	MGI:3852529
cx4	Nfkb1^tm1Brv/Nfkb1^tm1Brv Nfkb2^tm1Brv/Nfkb2⁺	involves: 129S1/Sv * C57BL/6	MGI:3852531

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Stomach abnormalities in Nfkb2^tm1Brv/Nfkb2^tm1Brv mice

mortality/aging

premature death ( J:43469 )

immune system

increased B cell proliferation ( J:43469 )

• LPS-induced B cell proliferation is increased compared to in similarly treated wild-type mice

increased T cell proliferation ( J:43469 )

• T cell proliferation in response to anti-CD3, anti-CD3 plus anti-CD28, or PMA plus PHA is two- to six-fold more efficient than for similarly treated wild-type cells

abnormal thymus corticomedullary boundary morphology ( J:43469 )

• poorly demarcated

thymus atrophy ( J:43469 )

• at 3 weeks

increased granulocyte number ( J:43469 )

• in the bone marrow and peripheral blood

abnormal lymphocyte cell number ( J:43469 )

• the ratio of T to B cell is slightly decreased in the lymph node compared to in wild-type mice

• however, lymphocyte development is normal

abnormal T cell number ( J:43469 )

• the percentage of T cells in the spleen is decreased compared to in wild-type mice

decreased double-positive T cell number ( J:43469 )

• at P10, CD4+CD8+ double positive thymic cells are nearly absent

abnormal T cell subpopulation ratio ( J:43469 )

• double positive T cells are nearly absent and single positive T cells predominate

intermingled spleen red and white pulp ( J:43469 )

• at 3 weeks

decreased spleen weight ( J:43469 )

• starting at P10 to P14

spleen atrophy ( J:43469 )

• at 3 weeks

spleen hypoplasia ( J:43469 )

• at 3 weeks

abnormal lymph node cortex morphology ( J:43469 )

• after 2 weeks, the paracortical area is increased compared to in wild-type mice

abnormal lymph node B cell domain morphology ( J:43469 )

• mice exhibit reduced number and cell density of lymphatic follicles compared to in wild-type mice

enlarged lymph nodes ( J:43469 )

• after 2 weeks

abnormal cytokine secretion ( J:43469 )

• anti-CD3 and anti-CD28-stimulated production of cytokines IL2, IL4, IL10, GM-CSF (granulocyte monocyte colony stimulating factor), and TNF-alpha is increased 5- to 35-fold compared to in similarly treated wild-type cells

increased interleukin-10 secretion ( J:43469 )

• following anti-CD3 and anti-CD28 stimulation

increased interleukin-2 secretion ( J:43469 )

• following anti-CD3 and anti-CD28 stimulation

increased interleukin-4 secretion ( J:43469 )

• following anti-CD3 and anti-CD28 stimulation

increased tumor necrosis factor secretion ( J:43469 )

• following anti-CD3 and anti-CD28 stimulation

digestive/alimentary system

abnormal stomach cardiac region morphology ( J:43469 )

• mice exhibit hyperkeratosis in the cardiac portion of the stomach unlike in wild-type mice

• at 3 weeks, gastric abnormalities increase in severity until the gastric lumen is occluded unlike in wild-type mice

stomach epithelial hyperplasia ( J:43469 )

• in the antrum with lymphocytic infiltrate in the lamina propria

small stomach ( J:43469 )

• at 2 weeks

growth/size/body

decreased body size ( J:43469 )

• at P10 to P14

decreased body weight ( J:43469 )

• after P10 to P14, mice weight 25% to 30% less than wild-type mice

weight loss ( J:43469 )

• after P10 to P14

behavior/neurological

abnormal food intake ( J:43469 )

• at 2 weeks, stomach contains little food or milk unlike wild-type mice

hunched posture ( J:43469 )

• after P10 to P14

skeleton

abnormal bone marrow morphology ( J:43469 )

• at 3 weeks, the number of granulocytes is increased and a reduced number of other hematopoeitic cell populations compared to in wild-type mice

hematopoietic system

increased B cell proliferation ( J:43469 )

• LPS-induced B cell proliferation is increased compared to in similarly treated wild-type mice

increased T cell proliferation ( J:43469 )

• T cell proliferation in response to anti-CD3, anti-CD3 plus anti-CD28, or PMA plus PHA is two- to six-fold more efficient than for similarly treated wild-type cells

abnormal thymus corticomedullary boundary morphology ( J:43469 )

• poorly demarcated

thymus atrophy ( J:43469 )

• at 3 weeks

abnormal definitive hematopoiesis ( J:43469 )

• hematopoietic abnormalities increase in severity by 3 weeks

anemia ( J:43469 )

• in the liver and spleen at 3 weeks

increased granulocyte number ( J:43469 )

• in the bone marrow and peripheral blood

abnormal lymphocyte cell number ( J:43469 )

• the ratio of T to B cell is slightly decreased in the lymph node compared to in wild-type mice

• however, lymphocyte development is normal

abnormal T cell number ( J:43469 )

• the percentage of T cells in the spleen is decreased compared to in wild-type mice

decreased double-positive T cell number ( J:43469 )

• at P10, CD4+CD8+ double positive thymic cells are nearly absent

abnormal T cell subpopulation ratio ( J:43469 )

• double positive T cells are nearly absent and single positive T cells predominate

intermingled spleen red and white pulp ( J:43469 )

• at 3 weeks

decreased spleen weight ( J:43469 )

• starting at P10 to P14

spleen atrophy ( J:43469 )

• at 3 weeks

spleen hypoplasia ( J:43469 )

• at 3 weeks

integument

disheveled coat ( J:43469 )

• after P10 to P14

endocrine/exocrine glands

abnormal thymus corticomedullary boundary morphology ( J:43469 )

• poorly demarcated

thymus atrophy ( J:43469 )

• at 3 weeks

cellular

increased B cell proliferation ( J:43469 )

• LPS-induced B cell proliferation is increased compared to in similarly treated wild-type mice

increased T cell proliferation ( J:43469 )

• T cell proliferation in response to anti-CD3, anti-CD3 plus anti-CD28, or PMA plus PHA is two- to six-fold more efficient than for similarly treated wild-type cells

Allelic Composition	Nfkb2^tm1Brv/Nfkb2⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2^tm1Brv mutation (0 available); any Nfkb2 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

stomach epithelial hyperplasia ( J:43469 )

• at 10 months, mice exhibit mild gastric hyperplasia compared to in wild-type mice

Allelic Composition	Nfkb1^tm1Brv/Nfkb1^tm1Brv Nfkb2^tm1Brv/Nfkb2^tm1Brv
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1^tm1Brv mutation (0 available); any Nfkb1 mutation (99 available)
Nfkb2^tm1Brv mutation (0 available); any Nfkb2 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal osteoclast differentiation ( J:44112 )

• fewer osteoclasts form while more bone-residing macrophages are detected compared to in wild-type mice

tooth impaction ( J:44112 )

• tooth eruption is prevented by a superficial bone plate on the mandible and maxilla and impacted teeth are poorly invested in the surrounding alveolar bone unlike in wild-type mice

• however, mice reconstituted with wild-type marrow exhibit only delayed tooth eruption

decreased osteoclast cell number ( J:44112 )

abnormal long bone morphology ( J:44112 )

• persistent cartilaginous and osseous trabecular are found throughout the epiphysis, metaphysis and diaphysis unlike in wild-type mice

• endochondral bones exhibit thin, hypocellular growth plates and wide, cavernous marrow spaces unlike in wild-type mice

abnormal long bone epiphyseal plate morphology ( J:44112 )

• the proliferating and hypertrophic zones are arranged in irregular clusters unlike the discrete columns observed in wild-type mice

abnormal bone marrow cavity morphology ( J:44112 )

• the bone marrow cavity is filled with unresorbed primary spongiosa that reduces the space 80% compared to in wild-type mice

osteopetrosis ( J:44112 )

immune system

abnormal osteoclast differentiation ( J:44112 )

• fewer osteoclasts form while more bone-residing macrophages are detected compared to in wild-type mice

decreased osteoclast cell number ( J:44112 )

increased macrophage cell number ( J:44112 )

• the number of bone-residing macrophages is increased compared to in wild-type mice

• the number of macrophages in the spleen, blood, and bone marrow is increased compared to in wild-type mice

abnormal cytokine secretion ( J:44112 )

• LPS and IFN-gamma-stimulated macrophages exhibit reduced IL6 and GM-CSF (granulocyte monocyte colony stimulating factor) production compared to similarly treated wild-type cell

decreased interleukin-6 secretion ( J:44112 )

• LPS and IFN-gamma-stimulated macrophages exhibit reduced IL6 production compared to similarly treated wild-type cell

growth/size/body

tooth impaction ( J:44112 )

• tooth eruption is prevented by a superficial bone plate on the mandible and maxilla and impacted teeth are poorly invested in the surrounding alveolar bone unlike in wild-type mice

• however, mice reconstituted with wild-type marrow exhibit only delayed tooth eruption

postnatal growth retardation ( J:44112 )

• after P10

craniofacial

abnormal craniofacial morphology ( J:44112 )

• after P10

tooth impaction ( J:44112 )

• tooth eruption is prevented by a superficial bone plate on the mandible and maxilla and impacted teeth are poorly invested in the surrounding alveolar bone unlike in wild-type mice

• however, mice reconstituted with wild-type marrow exhibit only delayed tooth eruption

hematopoietic system

abnormal osteoclast differentiation ( J:44112 )

• fewer osteoclasts form while more bone-residing macrophages are detected compared to in wild-type mice

decreased osteoclast cell number ( J:44112 )

increased macrophage cell number ( J:44112 )

• the number of bone-residing macrophages is increased compared to in wild-type mice

• the number of macrophages in the spleen, blood, and bone marrow is increased compared to in wild-type mice

cellular

abnormal osteoclast differentiation ( J:44112 )

• fewer osteoclasts form while more bone-residing macrophages are detected compared to in wild-type mice

Allelic Composition	Nfkb1^tm1Brv/Nfkb1^tm1Brv Nfkb2^tm1Brv/Nfkb2⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:44112 )

• mice exhibit only subtle changes in bone structure

abnormal osteoclast differentiation ( J:44112 )

• osteoclast differentiation is arrested before fusion

decreased osteoclast cell number ( J:44112 )

• no mature osteoclasts are detected in cultures of spleen cells unlike those of wild-type cell

immune system

abnormal osteoclast differentiation ( J:44112 )

• osteoclast differentiation is arrested before fusion

decreased osteoclast cell number ( J:44112 )

• no mature osteoclasts are detected in cultures of spleen cells unlike those of wild-type cell

hematopoietic system

abnormal osteoclast differentiation ( J:44112 )

• osteoclast differentiation is arrested before fusion

decreased osteoclast cell number ( J:44112 )

• no mature osteoclasts are detected in cultures of spleen cells unlike those of wild-type cell

cellular

abnormal osteoclast differentiation ( J:44112 )

• osteoclast differentiation is arrested before fusion

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24