Phenotypes associated with this allele

• Allele Symbol: Tnfrsf11b^tm1Eac
• Allele Name: targeted mutation 1, Edward A Clark
• Allele ID: MGI:2179712
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac	involves: 129S4/SvJaeSor	MGI:3852640
cx2	Apoe^tm1Unc/Apoe^tm1Unc Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac	involves: 129S4/SvJaeSor * C57BL/6	MGI:3852641

Genotype
MGI:3852640

hm1

• Allelic Composition: Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal mandible morphology ( J:67105 )

• thickened mandibular corpus

abnormal long bone morphology ( J:67105 )

• fractured diaphyses of long bones often seen in older mice

short femur neck ( J:67105 )

• shortened femoral neck in 2 month old mice

increased diameter of long bones ( J:67105 )

• increased outer diameter of long bones

abnormal bone structure ( J:67105 )

decreased bone mineral density ( J:67105 )

• dramatically reduced bone density in 3 month old males

abnormal compact bone morphology ( J:67105 )

• cortical bone is more porous

immune system

abnormal immune system morphology ( J:67105 )

abnormal pro-B cell differentiation ( J:67105 )

• defective pro-B cell to pre-B cell transition

increased pro-B cell number ( J:67105 )

• increased proliferative response to IL-7 (1.7-2 fold increase)

increased B cell number ( J:67105 )

• increased number of peripheral B cells

increased immature B cell number ( J:67105 )

• 53% more IgM (high) IgD (low) B cells

abnormal immune system physiology ( J:67105 )

abnormal immunoglobulin level ( J:67105 )

• variable ability to mount an antibody response

• antibody response is comparable to controls overall

abnormal dendritic cell antigen presentation ( J:67105 )

• enhanced ability to stimulate T-cell proliferation

limbs/digits/tail

short femur neck ( J:67105 )

• shortened femoral neck in 2 month old mice

craniofacial

abnormal mandible morphology ( J:67105 )

• thickened mandibular corpus

hematopoietic system

abnormal pro-B cell differentiation ( J:67105 )

• defective pro-B cell to pre-B cell transition

increased pro-B cell number ( J:67105 )

• increased proliferative response to IL-7 (1.7-2 fold increase)

increased B cell number ( J:67105 )

• increased number of peripheral B cells

increased immature B cell number ( J:67105 )

• 53% more IgM (high) IgD (low) B cells

abnormal immunoglobulin level ( J:67105 )

• variable ability to mount an antibody response

• antibody response is comparable to controls overall

Genotype
MGI:3852641

cx2

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

cardiovascular system

abnormal aorta morphology ( J:128053 )

• increased extractable calcium in the aorta at 40 and 60 weeks

abnormal brachiocephalic trunk morphology ( J:128053 )

• 38% show calcification of the medial layer of the brachiocephalic artery

• calcification of the intimal layer of the brachiocephalic artery by 40-60 weeks

atherosclerotic lesions ( J:128053 )

• increased area of lesions in the brachiocephalic artery at 40 and 60 weeks but not at 20 weeks

• increased number of lesions with laminated elastic fibers

• larger areas of collagen and proteoglycan deposition

• 40% addition reduction in lesion cellularity as compared to mice only homozygous for Apoe^tm1Unc