About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rph3atm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:2179730
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rph3atm1Sud/Rph3atm1Sud involves: 129P2/OlaHsd * C57BL/6J MGI:2179731
cx2
 		Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg
Rph3atm1Sud/Rph3atm1Sud
Syt7tm1Sud/Syt7tm1Sud 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7738542
cx3
 		Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Rph3atm1Sud/Rph3atm1Sud 		involves: 129P2/OlaHsd * C57BL/6 MGI:7738541


Genotype
MGI:2179731
hm1
Allelic
Composition		 Rph3atm1Sud/Rph3atm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rph3atm1Sud mutation (1 available); any Rph3a mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:7738542
cx2
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg
Rph3atm1Sud/Rph3atm1Sud
Syt7tm1Sud/Syt7tm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (15 available)
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (20 available)
Doc2gtm1.2Aljg mutation (0 available); any Doc2g mutation (11 available)
Rph3atm1Sud mutation (1 available); any Rph3a mutation (43 available)
Syt7tm1Sud mutation (1 available); any Syt7 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal synaptic plasticity ( J:317639 )
• short-term plasticity is altered by accentuating short-term depression
abnormal synaptic depression ( J:317639 )
• hippocampal neurons show more pronounced short-term depression
• the deeper short-term depression is not associated with changes in evoked release during burst stimuli
decreased paired-pulse ratio ( J:317639 )
• hippocampal neurons show reduced paired-pulse ratio with a more pronounced short-term depression
• however, spontaneous neurotransmitter release in glutamatergic hippocampal neurons is unaltered




Genotype
MGI:7738541
cx3
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Rph3atm1Sud/Rph3atm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (15 available)
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (20 available)
Rph3atm1Sud mutation (1 available); any Rph3a mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal miniature excitatory postsynaptic currents ( J:317639 )
• miniature excitatory postsynaptic current (mEPSC) release rate of hippocampal neurons in network cultures, but not in autapses, is increased indicating increased spontaneous glutamate release
• the normalized mEPSC frequency is increased and the decay is slightly, but significantly, faster
• however, the amplitude and rise time remains unchanged for hippocampal neurons and the frequency and kinetics of mEPSCs in autaptic neurons are unchanged
increased neurotransmitter release ( J:317639 )
• hippocampal neurons show an increase in spontaneous release frequency in network cultures, but not in autapses




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory