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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rph3atm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:2179730
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rph3atm1Sud/Rph3atm1Sud involves: 129P2/OlaHsd * C57BL/6J MGI:2179731
cx2
 		Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg
Rph3atm1Sud/Rph3atm1Sud
Syt7tm1Sud/Syt7tm1Sud 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7738542
cx3
 		Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Rph3atm1Sud/Rph3atm1Sud 		involves: 129P2/OlaHsd * C57BL/6 MGI:7738541


Genotype
MGI:2179731
hm1
Allelic
Composition		 Rph3atm1Sud/Rph3atm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rph3atm1Sud mutation (1 available); any Rph3a mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:7738542
cx2
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg
Rph3atm1Sud/Rph3atm1Sud
Syt7tm1Sud/Syt7tm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (15 available)
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (20 available)
Doc2gtm1.2Aljg mutation (0 available); any Doc2g mutation (11 available)
Rph3atm1Sud mutation (1 available); any Rph3a mutation (43 available)
Syt7tm1Sud mutation (1 available); any Syt7 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal synaptic plasticity ( J:317639 )
• short-term plasticity is altered by accentuating short-term depression
abnormal synaptic depression ( J:317639 )
• hippocampal neurons show more pronounced short-term depression
• the deeper short-term depression is not associated with changes in evoked release during burst stimuli
decreased paired-pulse ratio ( J:317639 )
• hippocampal neurons show reduced paired-pulse ratio with a more pronounced short-term depression
• however, spontaneous neurotransmitter release in glutamatergic hippocampal neurons is unaltered




Genotype
MGI:7738541
cx3
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Rph3atm1Sud/Rph3atm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (15 available)
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (20 available)
Rph3atm1Sud mutation (1 available); any Rph3a mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal miniature excitatory postsynaptic currents ( J:317639 )
• miniature excitatory postsynaptic current (mEPSC) release rate of hippocampal neurons in network cultures, but not in autapses, is increased indicating increased spontaneous glutamate release
• the normalized mEPSC frequency is increased and the decay is slightly, but significantly, faster
• however, the amplitude and rise time remains unchanged for hippocampal neurons and the frequency and kinetics of mEPSCs in autaptic neurons are unchanged
increased neurotransmitter release ( J:317639 )
• hippocampal neurons show an increase in spontaneous release frequency in network cultures, but not in autapses




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory