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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sv2atm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:2179736
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sv2atm1Sud/Sv2atm1Sud involves: 129P2/OlaHsd * C57BL/6 MGI:2180320
cx2
 		Sv2atm1Sud/Sv2a+
Sv2btm1Sud/Sv2btm1Sud 		involves: 129P2/OlaHsd * C57BL/6 MGI:2180321
cx3
 		Sv2atm1Sud/Sv2atm1Sud
Sv2btm1Sud/Sv2btm1Sud 		involves: 129P2/OlaHsd * C57BL/6 MGI:2180322


Genotype
MGI:2180320
hm1
Allelic
Composition		 Sv2atm1Sud/Sv2atm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sv2atm1Sud mutation (1 available); any Sv2a mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:59180 )
• those that survive the first few days after birth die between P16 and P21
neonatal lethality, incomplete penetrance ( J:59180 )
• 10% of animals die in the first few days after birth

behavior/neurological
seizures ( J:59180 )
• age of onset P8; increasing severity and frequency with age

growth/size/body
postnatal growth retardation ( J:59180 )
• at P8, postulated to be due to inability to feed due to seizure activity

nervous system
nervous system phenotype ( J:59180 )
N
• normal brain morphology
seizures ( J:59180 )
• age of onset P8; increasing severity and frequency with age




Genotype
MGI:2180321
cx2
Allelic
Composition		 Sv2atm1Sud/Sv2a+
Sv2btm1Sud/Sv2btm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sv2atm1Sud mutation (1 available); any Sv2a mutation (37 available)
Sv2btm1Sud mutation (1 available); any Sv2b mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:2180322
cx3
Allelic
Composition		 Sv2atm1Sud/Sv2atm1Sud
Sv2btm1Sud/Sv2btm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sv2atm1Sud mutation (1 available); any Sv2a mutation (37 available)
Sv2btm1Sud mutation (1 available); any Sv2b mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:59180 )
• 50% of animals die in the first few days after birth; the remainder die by P21

behavior/neurological
seizures ( J:59180 )
• age of onset P8; increasing severity and frequency with age

nervous system
nervous system phenotype ( J:59180 )
N
• normal brain morphology
seizures ( J:59180 )
• age of onset P8; increasing severity and frequency with age
decreased synaptic depression ( J:59180 )
• reduced short-term synaptic depression; 3-5 fold increase during repetitive stimulation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory