All Phenotypes Sv2b<tm1Sud> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sv2b^tm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:2179737

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sv2b^tm1Sud/Sv2b^tm1Sud	involves: 129P2/OlaHsd * C57BL/6	MGI:2180323
cx2	Sv2a^tm1Sud/Sv2a⁺ Sv2b^tm1Sud/Sv2b^tm1Sud	involves: 129P2/OlaHsd * C57BL/6	MGI:2180321
cx3	Sv2a^tm1Sud/Sv2a^tm1Sud Sv2b^tm1Sud/Sv2b^tm1Sud	involves: 129P2/OlaHsd * C57BL/6	MGI:2180322

Allelic Composition	Sv2b^tm1Sud/Sv2b^tm1Sud
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sv2b^tm1Sud mutation (1 available); any Sv2b mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:59180 )

nervous system

nervous system phenotype ( J:59180 )

N	• normal brain morphology

Allelic Composition	Sv2a^tm1Sud/Sv2a⁺ Sv2b^tm1Sud/Sv2b^tm1Sud
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sv2a^tm1Sud mutation (1 available); any Sv2a mutation (37 available)
Sv2b^tm1Sud mutation (1 available); any Sv2b mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:59180 )

Allelic Composition	Sv2a^tm1Sud/Sv2a^tm1Sud Sv2b^tm1Sud/Sv2b^tm1Sud
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:59180 )

• 50% of animals die in the first few days after birth; the remainder die by P21

behavior/neurological

seizures ( J:59180 )

• age of onset P8; increasing severity and frequency with age

nervous system

nervous system phenotype ( J:59180 )

N	• normal brain morphology

seizures ( J:59180 )

• age of onset P8; increasing severity and frequency with age

decreased synaptic depression ( J:59180 )

• reduced short-term synaptic depression; 3-5 fold increase during repetitive stimulation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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