Phenotypes associated with this allele

• Allele Symbol: Kcnab2^tm1Kmc
• Allele Name: targeted mutation 1, Ken McCormack
• Allele ID: MGI:2179738
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnab2^tm1Kmc/Kcnab2^tm1Kmc	B6.129S7-Kcnab2^tm1Kmc	MGI:3619240
hm2	Kcnab2^tm1Kmc/Kcnab2^tm1Kmc	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:3619241
hm3	Kcnab2^tm1Kmc/Kcnab2^tm1Kmc	involves: 129S7/SvEvBrd * C57BL/6	MGI:3619238
cx4	Kcnab1^tm1Mes/Kcnab1^tm1Mes Kcnab2^tm1Kmc/Kcnab2^tm1Kmc	involves: 129S7/SvEvBrd	MGI:3619243
cx5	Kcnab1^tm1Mes/Kcnab1^+ Kcnab2^tm1Kmc/Kcnab2^tm1Kmc	involves: 129S7/SvEvBrd	MGI:3619244

Genotype
MGI:3619240

hm1

• Allelic Composition: Kcnab2^tm1Kmc/Kcnab2^tm1Kmc
• Genetic Background: B6.129S7-Kcnab2^tm1Kmc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:106453 )

• Background Sensitivity: average life span 138 days in B6 congenics

behavior/neurological

tremors ( J:106453 )

• Background Sensitivity: cold induced tremors most severe in the B6 congenic background

homeostasis/metabolism

impaired adaptive thermogenesis ( J:106453 )

• Background Sensitivity: drop in core body temperature due to cold swimming greatest in a B6 congenic background

growth/size/body

decreased body size ( J:106453 )

• mice on a B6 congenic background about 11% smaller than controls, about the size of 129 mice

Genotype
MGI:3619241

hm2

• Allelic Composition: Kcnab2^tm1Kmc/Kcnab2^tm1Kmc
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

mortality/aging

premature death ( J:106453 )

• Background Sensitivity: average life span longer but never the less reduced to an undetermined extent on a 129 background

behavior/neurological

tremors ( J:106453 )

• Background Sensitivity: cold induced tremors rare in a 129 background

homeostasis/metabolism

decreased core body temperature ( J:106453 )

• Background Sensitivity: drop in core body temperature is lowest on a 129 background compared to other genetic backgrounds

Genotype
MGI:3619238

hm3

• Allelic Composition: Kcnab2^tm1Kmc/Kcnab2^tm1Kmc
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

mortality/aging

premature death ( J:75891 )

• Background Sensitivity: average life span about 255 days on mixed background

behavior/neurological

behavior/neurological phenotype ( J:167856 )

N • mice exhibit normal locomotion, anxiety-related behavior, and auditory response

abnormal learning/memory/conditioning ( J:167856 )

• mice exhibit impaired associative learning compared with wild-type mice

impaired contextual conditioning behavior ( J:167856 )

abnormal spatial learning ( J:167856 )

• in a Morris water maze, mice exhibit a non-selective search strategy compared with wild-type mice

• however, sensory motor function in a Morris water maze is normal

tremors ( J:75891 )

• Background Sensitivity: induced by swimming in cold water (17C) but not by swimming in warm water (37C)

sporadic seizures ( J:75891 )

nervous system

sporadic seizures ( J:75891 )

abnormal nervous system electrophysiology ( J:167856 )

• in response to increased current injection, neurons in the lateral amygdala exhibit more spikes compared with wild-type cells

abnormal afterhyperpolarization ( J:167856 )

• mice exhibit smaller postburst aftethyperpolarization compared to in wild-type mice

homeostasis/metabolism

decreased core body temperature ( J:106453 )

• Background Sensitivity: drop in core body temperature is moderate on a mixed background compared to other genetic backgrounds

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:167856 )

N • mice exhibit normal auditory brainstem response

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chromosome 1p36 deletion syndrome		DOID:0060410	OMIM:607872	J:167856

Genotype
MGI:3619243

cx4

• Allelic Composition: Kcnab1^tm1Mes/Kcnab1^tm1Mes; Kcnab2^tm1Kmc/Kcnab2^tm1Kmc
• Genetic Background: involves: 129S7/SvEvBrd

mortality/aging

premature death ( J:106453 )

• average life span about 114 days

Genotype
MGI:3619244

cx5

• Allelic Composition: Kcnab1^tm1Mes/Kcnab1⁺; Kcnab2^tm1Kmc/Kcnab2^tm1Kmc
• Genetic Background: involves: 129S7/SvEvBrd

mortality/aging

premature death ( J:106453 )

• average life span about 133 days