Phenotypes associated with this allele

• Allele Symbol: Nrcam^tm1Fgr
• Allele Name: targeted mutation 1, Fritz G Rathjen
• Allele ID: MGI:2179756
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrcam^tm1Fgr/Nrcam^tm1Fgr	involves: 129P2/OlaHsd * C57BL/6	MGI:2181779

Genotype
MGI:2181779

hm1

• Allelic Composition: Nrcam^tm1Fgr/Nrcam^tm1Fgr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:70385 )

• impaired motor coordination in rotarod test; homozygous mice fell from rod at higher frequency

growth/size/body

decreased body weight ( J:70385 )

• smaller than littermates, noticeable at birth; by P15-35, animals are 80% of the weight of control littermates, on average

vision/eye

disorganized secondary lens fibers ( J:70385 )

• apparent by 2 months of age

nuclear cataract ( J:70385 )

• nuclear opacity beginning at 1 month of age, progressive; 9 month old mice have completely opaque lenses