mortality/aging
• animals surviving past P1 die within 15 days of birth
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• incomplete penetrance; 85% of homozygous animals die within 24 hours of birth
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behavior/neurological
• episodic convulsions were noted in homozygous mice
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growth/size/body
• animals are significantly smaller than controls; a 3-fold weight difference was noted at P10
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nervous system
• episodic convulsions were noted in homozygous mice
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• amplitude and duration of synaptic depression was enhanced in homozygous mice after stimulatory conditions
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