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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Synj1tm1Pdc
targeted mutation 1, Pietro De Camilli
MGI:2179801
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Synj1tm1Pdc/Synj1tm1Pdc involves: 129S1/Sv * C57BL/6 MGI:2181801


Genotype
MGI:2181801
hm1
Allelic
Composition
Synj1tm1Pdc/Synj1tm1Pdc
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Synj1tm1Pdc mutation (1 available); any Synj1 mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals surviving past P1 die within 15 days of birth
• incomplete penetrance; 85% of homozygous animals die within 24 hours of birth

behavior/neurological
• severe weakness was noted in homozygotes surviving past P1
• episodic convulsions were noted in homozygous mice

growth/size/body
• animals are significantly smaller than controls; a 3-fold weight difference was noted at P10

nervous system
• episodic convulsions were noted in homozygous mice
• amplitude and duration of synaptic depression was enhanced in homozygous mice after stimulatory conditions





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory