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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trpc2tm1Rax
targeted mutation 1, Richard Axel
MGI:2179812
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trpc2tm1Rax/Trpc2tm1Rax involves: 129S/SvEv MGI:4819738
hm2
Trpc2tm1Rax/Trpc2tm1Rax involves: 129S/SvEv * C57BL/6J MGI:2655432


Genotype
MGI:4819738
hm1
Allelic
Composition
Trpc2tm1Rax/Trpc2tm1Rax
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc2tm1Rax mutation (0 available); any Trpc2 mutation (98 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• ESP1(Gm6084)-stimulated female mice fail to exhibit an increase in lordosis behavior and successful intromission by males unlike similarly treated wild-type mice




Genotype
MGI:2655432
hm2
Allelic
Composition
Trpc2tm1Rax/Trpc2tm1Rax
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc2tm1Rax mutation (0 available); any Trpc2 mutation (98 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• naive male homozygotes rarely initiate biting attacks in a resident-intruder assay, with only 4.3% displaying aggressive attack behavior towards a male intruder vs 64% of controls; all measures of aggressive behavior (latency to attack, attack frequency and attack duration) are significantly diminished
• absence of intermale aggression cannot be enhanced by prior mating or fighting experience
• furthermore, all lactating female homozygotes fail to initiate attacks toward intruder males in a maternal aggression assay
• although both mutant and control males mark in a dominant fashion before a fighting experience, male homozygotes become subordinated and suppress territorial marking after repetitive pairing with controls; in 91% of cases the control is dominant over the mutant, as assessed by marking
• after repetitive pairing, analysis of territorial marking patterns of mutant pairs indicates that male homozygotes do not form normal dominant-subordinate relationships
• both naive and sexually inexperienced male homozygotes display normal sexual behavior toward estrous females; however, upon exposure to wild-type intruder males for 15 min, sexually inexperienced, singly housed males show a 6-fold increase in the number of intermale mounts relative to control mice
• sexually experienced male homozygotes show a 16-fold increase in the frequency of male-male mounting relative to control males
• male homozygotes show a significantly higher number of intermale mounts than controls both before and after mating experience with females
• in fact, male homozygotes continue to mount males at a high rate even when a female is present in the home cage

nervous system
• homozygotes display a striking reduction in the electrophysiological responses of vomeronasal sensory neurons to synthetic and natural pheromones relative to wild-type and heterozygous control mice
• unlike control mice, homozygotes fail to respond to 2-heptanone at 10-7 M, and exhibit only a small response to 2-heptanone at 10-4 M; on average, the size of the electro-vomeronasogram (EVG) response to 2-heptanone at 10-4 M is reduced to ~25% of control mice
• unlike control mice, homozygotes fail to elicit a urine-evoked field potential at dilutions of urine of 1/105, while peak EVG responses to female or male urine, at dilutions of 1/102, are reduced to ~37% of wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory