About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trpc2tm1Rax
targeted mutation 1, Richard Axel
MGI:2179812
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trpc2tm1Rax/Trpc2tm1Rax involves: 129S/SvEv MGI:4819738
hm2
Trpc2tm1Rax/Trpc2tm1Rax involves: 129S/SvEv * C57BL/6J MGI:2655432


Genotype
MGI:4819738
hm1
Allelic
Composition
Trpc2tm1Rax/Trpc2tm1Rax
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc2tm1Rax mutation (0 available); any Trpc2 mutation (98 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• ESP1(Gm6084)-stimulated female mice fail to exhibit an increase in lordosis behavior and successful intromission by males unlike similarly treated wild-type mice




Genotype
MGI:2655432
hm2
Allelic
Composition
Trpc2tm1Rax/Trpc2tm1Rax
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc2tm1Rax mutation (0 available); any Trpc2 mutation (98 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• naive male homozygotes rarely initiate biting attacks in a resident-intruder assay, with only 4.3% displaying aggressive attack behavior towards a male intruder vs 64% of controls; all measures of aggressive behavior (latency to attack, attack frequency and attack duration) are significantly diminished
• absence of intermale aggression cannot be enhanced by prior mating or fighting experience
• furthermore, all lactating female homozygotes fail to initiate attacks toward intruder males in a maternal aggression assay
• although both mutant and control males mark in a dominant fashion before a fighting experience, male homozygotes become subordinated and suppress territorial marking after repetitive pairing with controls; in 91% of cases the control is dominant over the mutant, as assessed by marking
• after repetitive pairing, analysis of territorial marking patterns of mutant pairs indicates that male homozygotes do not form normal dominant-subordinate relationships
• both naive and sexually inexperienced male homozygotes display normal sexual behavior toward estrous females; however, upon exposure to wild-type intruder males for 15 min, sexually inexperienced, singly housed males show a 6-fold increase in the number of intermale mounts relative to control mice
• sexually experienced male homozygotes show a 16-fold increase in the frequency of male-male mounting relative to control males
• male homozygotes show a significantly higher number of intermale mounts than controls both before and after mating experience with females
• in fact, male homozygotes continue to mount males at a high rate even when a female is present in the home cage

nervous system
• homozygotes display a striking reduction in the electrophysiological responses of vomeronasal sensory neurons to synthetic and natural pheromones relative to wild-type and heterozygous control mice
• unlike control mice, homozygotes fail to respond to 2-heptanone at 10-7 M, and exhibit only a small response to 2-heptanone at 10-4 M; on average, the size of the electro-vomeronasogram (EVG) response to 2-heptanone at 10-4 M is reduced to ~25% of control mice
• unlike control mice, homozygotes fail to elicit a urine-evoked field potential at dilutions of urine of 1/105, while peak EVG responses to female or male urine, at dilutions of 1/102, are reduced to ~37% of wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory